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EFFECT OF CHRONIC SILDENAFIL TREATMENT ON THE PROSTATE OF C57BL/6 MICE
Inibidor da Nucleotídeo Cíclico Fosfodiesterase do Tipo 5
Próstata
tratamento farmacológico
Piperazinas
administração & dosagem
Próstata
ultraestrutura
ulfonamidas
administração & dosagem
Animais
Humanos
Disfunção Erétil
sangue
Disfunção Erétil
patologia
Hipertensão Pulmonar
tratamento farmacológico
Masculino
Camundongos Endogâmicos C57BL
Óxido Nítrico Sintase Tipo III
sangue
Antígeno Prostático Específico
sangue
Purinas
administração & dosagem
Testosterona
sangue
Fator de Crescimento Transformador beta
sangue
Citrato de Sildenafila
Author
Affilliation
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.
Abstract
Sildenafil is a potent and selective inhibitor of phosphodiesterase-5 (PDE5) and is considered first-line therapy for erectile dysfunction. Nowadays, Sildenafil is used extensively throughout the world on patients with pulmonary hypertension. However, few studies have evaluated the possible side effects of chronic Sildenafil treatment on the male reproductive system, specifically in the prostate. In the present study, it was demonstrated via morphological and ultrastructural analysis that chronic treatment with Sildenafil induced an enhancement of the glandular activity of the prostate. In addition, mice treated with Sildenafil showed a significant increase in testosterone serum levels. However, no statistically significant differences were observed in nitric oxide serum levels, or in sGC, eNOS, PSA and TGF-β prostatic expression. In conclusion, the present study suggests that chronic use of Sildenafil does not cause evident prostatic damage, and therefore, can be used pharmacologically to treat a variety of disorders.
Keywords in Portuguese
SildenafilaInibidor da Nucleotídeo Cíclico Fosfodiesterase do Tipo 5
Próstata
DeCS
Disfunção Erétiltratamento farmacológico
Piperazinas
administração & dosagem
Próstata
ultraestrutura
ulfonamidas
administração & dosagem
Animais
Humanos
Disfunção Erétil
sangue
Disfunção Erétil
patologia
Hipertensão Pulmonar
tratamento farmacológico
Masculino
Camundongos Endogâmicos C57BL
Óxido Nítrico Sintase Tipo III
sangue
Antígeno Prostático Específico
sangue
Purinas
administração & dosagem
Testosterona
sangue
Fator de Crescimento Transformador beta
sangue
Citrato de Sildenafila
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