| Author | Albuquerque, Cassiano Felippe Gonçalves de | |
| Author | Silva, Adriana Ribeiro | |
| Author | Silva, Camila Ignácio da | |
| Author | Faria Neto, Hugo Caire de Castro | |
| Author | Burth, Patrícia | |
| Access date | 2017-11-21T16:36:33Z | |
| Available date | 2017-11-21T16:36:33Z | |
| Document date | 2017 | |
| Citation | ALBUQUERQUE, Cassiano Felippe Gonçalves de; et al. Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy. Moelcules, v.22:578, 18p, 2017. | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/23297 | |
| Language | eng | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Apoptose | pt_BR |
| Subject in Portuguese | Autofagia | pt_BR |
| Subject in Portuguese | Carcinoma Pulmonar de Células não Pequenas | pt_BR |
| Subject in Portuguese | Glicosídeos Cardíacos | pt_BR |
| Title | Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.3390/molecules22040578 | |
| Abstract | Lung cancer is a leading cause of global cancer deaths. Na/K-ATPase has been studied as a target for cancer treatment. Cardiotonic steroids (CS) trigger intracellular signalling upon binding to Na/K-ATPase. Normal lung and tumour cells frequently express different pump isoforms. Thus, Na/K-ATPase is a powerful target for lung cancer treatment. Drugs targeting Na/K-ATPase may induce apoptosis and autophagy in transformed cells. We argue that Na/K-ATPase has a role as a potential target in chemotherapy in lung cancer treatment. We discuss the effects of Na/K-ATPase ligands and molecular pathways inducing deleterious effects on lung cancer cells, especially those leading to apoptosis and autophagy. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil / Universidade Federal do Estado do Rio de Janeiro. Departamento de Bioquímica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Celular e Molecular. Laboratório de Enzimologia e Sinalização Celular. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Celular e Molecular. Laboratório de Enzimologia e Sinalização Celular. Niterói, RJ, Brasil. | pt_BR |
| Subject | Na/K-ATPase | pt_BR |
| Subject | non-small cell lung cancer | pt_BR |
| Subject | apoptosis | pt_BR |
| Subject | autophagy | pt_BR |
| Subject | cardiotonic steroids | pt_BR |
| e-ISSN | 1420-3049 | |
