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NA/K PUMP AND BEYOND: NA/K-ATPASE AS A MODULATOR OF APOPTOSIS AND AUTOPHAGY
Albuquerque, Cassiano Felippe Gonçalves de et al. | Date Issued: 2017
Author
Albuquerque, Cassiano Felippe Gonçalves de
Silva, Adriana Ribeiro
Silva, Camila Ignácio da
Faria Neto, Hugo Caire de Castro
Burth, Patrícia
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil / Universidade Federal do Estado do Rio de Janeiro. Departamento de Bioquímica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.
Universidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Celular e Molecular. Laboratório de Enzimologia e Sinalização Celular. Niterói, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.
Universidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Celular e Molecular. Laboratório de Enzimologia e Sinalização Celular. Niterói, RJ, Brasil.
Abstract
Lung cancer is a leading cause of global cancer deaths. Na/K-ATPase has been studied as a target for cancer treatment. Cardiotonic steroids (CS) trigger intracellular signalling upon binding to Na/K-ATPase. Normal lung and tumour cells frequently express different pump isoforms. Thus, Na/K-ATPase is a powerful target for lung cancer treatment. Drugs targeting Na/K-ATPase may induce apoptosis and autophagy in transformed cells. We argue that Na/K-ATPase has a role as a potential target in chemotherapy in lung cancer treatment. We discuss the effects of Na/K-ATPase ligands and molecular pathways inducing deleterious effects on lung cancer cells, especially those leading to apoptosis and autophagy.
Keywords in Portuguese
Apoptose
Autofagia
Carcinoma Pulmonar de Células não Pequenas
Glicosídeos Cardíacos
 
Keywords
Na/K-ATPase
non-small cell lung cancer
apoptosis
autophagy
cardiotonic steroids
 
Publisher
MDPI
Citation
ALBUQUERQUE, Cassiano Felippe Gonçalves de; et al. Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy. Moelcules, v.22:578, 18p, 2017.
DOI
10.3390/molecules22040578