Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/23324
Title: Behavioral, climatic, and environmental risk factors for Zika and Chikungunya virus infections in Rio de Janeiro, Brazil, 2015-16
Authors: Fuller, Trevon L.
Calvet, Guilherme
Estevam, Camila Genaro
Angelo, Jussara Rafael
Abiodun, Gbenga J.
Halai, Umme-Aiman
Santis, Bianca de
Sequeira, Patricia Carvalho
Araujo, Eliane Machado
Sampaio, Simone Alves
Mendonça, Marco Cesar Lima de
Fabri, Allison
Ribeiro, Rita Maria
Harrigan, Ryan
Smith, Thomas B.
Gabaglia, Claudia Raja
Brasil, Patrícia
Filippis, Ana Maria Bispo de
Nielsen-Saines, Karin
Affilliation: University of California Los Angeles. Institute of the Environment and Sustainability. Los Angeles, CA, USA.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Universidade Estadual de São Paulo. Rio Claro, São Paulo, SP, Brasil.
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Rio de Janeiro, RJ, Brasil.
Foundation for Professional Development.Pretoria, Gauteng, South Africa.
David Geffen UCLA School of Medicine. Los Angeles, CA, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Referência de Flavivírus. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Referência de Flavivírus. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Referência de Flavivírus. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Referência de Flavivírus. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Referência de Flavivírus. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Referência de Flavivírus. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Referência de Flavivírus. Rio de Janeiro, RJ. Brasil.
University of California Los Angeles. Institute of the Environment and Sustainability. Los Angeles, CA, USA.
University of California Los Angeles. Institute of the Environment and Sustainability. Los Angeles, CA, USA / University of California Los Angeles. Department of Ecology and Evolutionary Biology. Los Angeles, CA, USA.
Biomedical Research Institute of Southern California. Oceanside, California, USA.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Referência de Flavivírus. Rio de Janeiro, RJ. Brasil.
David Geffen UCLA School of Medicine. Los Angeles, CA, USA.
Abstract: The burden of arboviruses in the Americas is high and may result in long-term sequelae with infants disabled by Zika virus infection (ZIKV) and arthritis caused by infection with Chikungunya virus (CHIKV). We aimed to identify environmental drivers of arbovirus epidemics to predict where the next epidemics will occur and prioritize municipalities for vector control and eventual vaccination. We screened sera and urine samples (n = 10,459) from residents of 48 municipalities in the state of Rio de Janeiro for CHIKV, dengue virus (DENV), and ZIKV by molecular PCR diagnostics. Further, we assessed the spatial pattern of arbovirus incidence at the municipal and neighborhood scales and the timing of epidemics and major rainfall events. Lab-confirmed cases included 1,717 infections with ZIKV (43.8%) and 2,170 with CHIKV (55.4%) and only 29 (<1%) with DENV. ZIKV incidence was greater in neighborhoods with little access to municipal water infrastructure (r = -0.47, p = 1.2x10-8). CHIKV incidence was weakly correlated with urbanization (r = 0.2, p = 0.02). Rains began in October 2015 and were followed one month later by the largest wave of ZIKV epidemic. ZIKV cases markedly declined in February 2016, which coincided with the start of a CHIKV outbreak. Rainfall predicted ZIKV and CHIKV with a lead time of 3 weeks each time. The association between rainfall and epidemics reflects vector ecology as the larval stages of Aedes aegypti require pools of water to develop. The temporal dynamics of ZIKV and CHIKV may be explained by the shorter incubation period of the viruses in the mosquito vector; 2 days for CHIKV versus 10 days for ZIKV.
Keywords: Zika virus
Risk factors
Infection
Brazil
Chikungunya virus
keywords: Zika Virus
Chikungunya virus
Fatores de risco
Infecção
Issue Date: 2017
Publisher: Public Library of Science
Citation: FULLER, Trevon L. et al. Behavioral, climatic, and environmental risk factors for Zika and Chikungunya virus infections in Rio de Janeiro, Brazil, 2015-16. PLoS ONE, v.12, n.11, e0188002, 15p, Nov. 2017.
DOI: 10.1371/journal.pone.0188002
ISSN: 1932-6203
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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