Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/23399

Type
Article
Copyright
Open access
Collections
Share

Statistics
Metadata
Show full item record

ASSOCIATION OF HIV DIVERSITY AND VIROLOGIC OUTCOMES IN EARLY ANTIRETROVIRAL TREATMENT: HPTN 052
Palumbo, Philip J. et al. | Date Issued: 2017
Author
Palumbo, Philip J.
Wilson, Ethan A.
Piwowar-Manning, Estelle
McCauley, Marybeth
Gamble, Theresa
Kumwenda, Newton
Makhema, Joseph
Kumarasamy, Nagalingeswaran
Chariyalertsak, Suwat
Hakim, James G.
Hosseinipour, Mina C.
Melo, Marineide G.
Godbole, Sheela V.
Pilotto, Jose H.
Grinsztejn, Beatriz
Panchia, Ravindre
Chen, Ying Q.
Cohen, Myron S.
Eshleman, Susan H.
Fogel, Jessica M.
Affilliation
Johns Hopkins University School of Medicine. Dept. of Pathology. Baltimore, Maryland, USA.
Fred Hutchinson Cancer Research Center. Divisions of Vaccine and Infectious Disease. Seattle, Washington, USA.
Johns Hopkins Univ. School of Medicine. Dept. of Pathology. Baltimore, Maryland, USA.
Science Facilitation Department, FHI 360. Washington, DC, USA.
Science Facilitation Department, FHI 360. Durham, NC, USA.
College of Medicine. Johns Hopkins Project. Blantyre, Malawi.
Botswana-Harvard AIDS Institute Partnership. Gaborone, Botswana.
CART CRS, YRGCARE Medical Centre, VHS. Chennai, India.
Chiang Mai University. Research Institute for Health Sciences. Chiang Mai, Thailand.
University of Zimbabwe. Dept. of Medicine. Harare, Zimbabwe.
University of North Carolina at Chapel Hill. Division of Infectious Diseases. Chapel Hill, NC, USA / Institute for Global Health and Infectious Diseases. UNC Project-Malawi. Lilongwe, Malawi.
Hospital Nossa Senhora da Conceição. Serviço de Infectologia. Porto Alegre, RS, Brasil.
National AIDS Research Institute. Pune, India.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil / Hospital Geral de Nova Iguaçu. Nova Iguaçu, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.
University of the Witwatersrand. Perinatal HIV Research Unit. Soweto HPTN CRS, Soweto, South Africa.
Fred Hutchinson Cancer Research Center. Divisions of Vaccine and Infectious Disease. Seattle, Washington, USA.
University of North Carolina at Chapel Hill. Dept. of Medicine. Chapel Hill, NC, USA.
Johns Hopkins University School of Medicine. Dept. of Pathology. Baltimore, Maryland, USA.
Johns Hopkins University School of Medicine. Dept. of Pathology. Baltimore, Maryland, USA.
Abstract
Higher HIV diversity has been associated with virologic outcomes in children on antiretroviral treatment (ART). We examined the association of HIV diversity with virologic outcomes in adults from the HPTN 052 trial who initiated ART at CD4 cell counts of 350-550 cells/mm3. A high resolution melting (HRM) assay was used to analyze baseline (pre-treatment) HIV diversity in six regions in the HIV genome (two in gag, one in pol, and three in env) from 95 participants who failed ART. We analyzed the association of HIV diversity in each genomic region with baseline (pre-treatment) factors and three clinical outcomes: time to virologic suppression after ART initiation, time to ART failure, and emergence of HIV drug resistance at ART failure. After correcting for multiple comparisons, we did not find any association of baseline HIV diversity with demographic, laboratory, or clinical characteristics. For the 18 analyses performed for clinical outcomes evaluated, there was only one significant association: higher baseline HIV diversity in one of the three HIV env regions was associated with longer time to ART failure (p = 0.008). The HRM diversity assay may be useful in future studies exploring the relationship between HIV diversity and clinical outcomes in individuals with HIV infection.
Keywords in Portuguese
HIV
Tratamento antiretrovial
Infecção experimental
Resultados virológicos
 
Keywords
HIV diversity
Antiretroviral treatment
Infection
Virologic outcomes
 
Publisher
Public Library of Science
Citation
PALUMBO, Philip J. et al. Association of HIV diversity and virologic outcomes in early antiretroviral treatment: HPTN 052. PLoS One, v. 12, n. 5, p. 1-9, May 2017.
DOI
10.1371/journal.pone.0177281
ISSN
1932-6203