Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/23469
Title: Increased circulating procoagulant and anticoagulant factors as TF and TFPI according to severity or infecting serotypes in human dengue infection
Authors: Azeredo, Elzinandes Leal de
Solórzano, Victor Edgar Fiestas
Oliveira, Débora Batista de
Marinho, Cintia Ferreira
Souza, Luiz José de
Cunha, Rivaldo Venâncio da
Damasco, Paulo Vieira
Kubelka, Claire Fernandes
Pinto, Luzia Maria de Oliveira
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.
Centro de Referência para Dengue. Campos de Goyytacazes, RJ, Brasil.
Universidade Federal do Mato Grosso do Sul. Departamento de Clínica Médica. Campo Grande, MS, Brasil.
Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffreé Guinle. Rio-Laranjeiras Hospital. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro.. Hospital Universitário Pedro Ernesto. Rio de Janeiro, RJ, Brasil .
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.
Abstract: Tissue Factor (TF) is the initiator of coagulation and Tissue Factor Inhibitor (TFPI) is the physiological inhibitor of the TF/FVIIa complex. Circulating levels of TF and TFPI were quantified in dengue patients and the relationships with disease severity and infecting serotype analysed. A significant decrease in TF and TPFI plasma levels was observed in mild DF patients compared with severe dengue. Furthermore, both factors were associated with haemorrhagic manifestations. Finally, TF levels were significantly increased in DENV-1/2 infected patients as compared with DENV-4. These findings suggest that activation of TF-pathway is an important component of DENV -related coagulation disorders.
Keywords: TFPI
TF
Dengue
keywords: Dengue
Tromboplastina
Inibidor
Issue Date: 2017
Publisher: Elsevier
Citation: AZEREDO, Elzinandes Leal de; et al. Increased circulating procoagulant and anticoagulant factors as TF and TFPI according to severity or infecting serotypes in human dengue infection. Microbes and Infection, v.19, p.62-68, 2017.
DOI: 10.1016/j.micinf.2016.08.005
ISSN: 1286-4579
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

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