Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/23485
Title: Evaluation of the response to treatment with Benznidazole of mice with triple infection with clones 0f 21SF strain (S. FELIPE-BA) of Trypanosoma Cruzi with different degrees of susceptibility to chemotherapy in comparison with mice with single infection
Authors: Rebouças, M. C
Guerreiro, Marcos Lázaro da Silva
Andrade, Sonia Gumes
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Chagas Experimental Autoimunidade e Imunologia Celular. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Chagas Experimental Autoimunidade e Imunologia Celular. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Chagas Experimental Autoimunidade e Imunologia Celular. Salvador, BA, Brasil
Abstract: Introduction: People living in endemic areas of Chagas disease are submitted to multiple infections during their lives and could be infected with strains or clones with different virulence and susceptibility to chemotherapy. This is an important factor in the development and morbidity of the disease. Strains of Trypanosoma cruzi represent complex multiclonal populations, which can be homogeneous or heterogeneous with predominance of a principal clone. The strains are biologically classified in different Biodemes (Types I, II and III) which disclose different degrees of resistance to chemotherapy. Type I strains are very susceptible to treatment. Type II strains disclose medium susceptibility (21SF strain); strains of Type III are very resistant (Colombian strain). The clones isolated from different strains can also present different degrees of resistance. In the present study the results of treatment of mice triple infected with clones of the 21SF strain is evaluated, in comparison with the infected with the parental strain
Keywords: Trypanosoma cruzi
Chagas disease
Chemotherapy
Mice
Infection
keywords: Trypanosoma cruzi
Doença de Chagas
Quimioterapia
Camundogos
Infecção
Issue Date: 2012
Publisher: Sociedade Brasileira de Medicina Tropical
Citation: REBOUÇAS, M. C.; GUERREIRO, M. L.; ANDRADE, S. G. Evaluation of the response to treatment with Benznidazole of mice with triple infection with clones 0f 21SF strain (S. FELIPE-BA) of Trypanosoma Cruzi with different degrees of susceptibility to chemotherapy in comparison with mice with single infection. In: Congresso Internacional de Medicina Tropical e Malária, 18 e Congresso da Sociedade Brasileira de Medicina Tropical, 48., 2012, Rio de Janeiro. Resumos... Rio de Janeiro: Sociedade Brasileira de Medicina Tropical, 2012.
Copyright: open access
Appears in Collections:BA - IGM - Trabalhos Apresentados em Eventos

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