Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/23532
Title: Tracing the origin of the NS1 A188V substitution responsible for recent enhancement of Zika virus Asian genotype infectivity
Authors: Delatorre, Edson
Mir, Daiana
Bello, Gonzalo
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.
Abstract: A recent study showed that infectivity of Zika virus (ZIKV) Asian genotype was enhanced by an alanine-to-valine amino acid substitution at residue 188 of the NS1 protein, but the precise time and location of origin of this mutation were not formally estimated. Here, we applied a Bayesian coalescent-based framework to estimate the age and location of the ancestral viral strain carrying the A188V substitution. Our results support that the ancestral ZIKV strain carrying the A188V substitution arose in Southeastern Asia at the early 2000s and circulated in that region for some time (5-10 years) before being disseminated to Southern Pacific islands and the Americas.
Keywords: Zika Virus
NS1
infectivity
evolution
keywords: Zika Virus
NS1
patogenicidade
Evolução
Issue Date: 2017
Publisher: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
Citation: DELATORRE, Edson; MIR, Daiana; BELLO, Gonzalo. Tracing the origin of the NS1 A188V substitution responsible for recent enhancement of Zika virus Asian genotype infectivity. Mem Inst Oswaldo Cruz, v.112, n.11, p.793-795, Nov. 2017.
DOI: 10.1590/0074-02760170299
ISSN: 0074-0276
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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