Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/23559
Title: Evaluation of anti-Trypanosoma cruzi activities of nitrosyl/nitro ruthenium complexes in vitro and in vivo
Authors: Bastos, Tanira Matutino
Barbosa, Marília Imaculada Frazão
Meira, Cássio Santana
Guimarães, Elisalva Teixeira
Batista, Alzir Azevedo
Soares, Milena Botelho Pereira
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal de São Carlos. Departamento de Química. São Carlos, SP, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal de São Carlos. Departamento de Química. São Carlos, SP, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, Brasil
Abstract: enznidazole has been used to treat Chagas disease since the decade of 70ies. Both drugs are effective in acute phase or recent chronic phase of the disease, but they can induce side effects for the patients. Therefore, more efficient drugs with lower toxicity are need for the treatment of this disease. Synthesis of transition metal compounds, especially ruthenium, has increased over the years and data have shown many biological applications of these compounds.
Keywords: Trypanosoma cruzi
Chagas disease
Drugs
Ruthenium compounds
Animals
Mice
keywords: Trypanosoma cruzi
Doença de Chagas
Droga
Compostos de rutênio
Animais
Camundongos
Issue Date: 2012
Publisher: Sociedade Brasileira de Medicina Tropical
Citation: BASTOS, T. M. et al. Evaluation of anti-Trypanosoma cruzi activities of nitrosyl/nitro ruthenium complexes in vitro and in vivo. In: CONGRESSO INTERNACIONAL DE MEDICINA TROPICAL E MALÁRIA, 18 e CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 48., 2012, Rio de Janeiro. Resumos... Rio de Janeiro: Sociedade Brasileira de Medicina Tropical, 2012.
Copyright: open access
Appears in Collections:BA - IGM - Trabalhos Apresentados em Eventos

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