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EVALUATION OF ANTI-TRYPANOSOMA CRUZI ACTIVITIES OF NITROSYL/NITRO RUTHENIUM COMPLEXES IN VITRO AND IN VIVO
Bastos, Tanira Matutino et al. | Date Issued: 2012
Author
Bastos, Tanira Matutino
Barbosa, Marília Imaculada Frazão
Meira, Cássio Santana
Guimarães, Elisalva Teixeira
Batista, Alzir Azevedo
Soares, Milena Botelho Pereira
Affilliation
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal de São Carlos. Departamento de Química. São Carlos, SP, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal de São Carlos. Departamento de Química. São Carlos, SP, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, Brasil
Abstract
enznidazole has been used to treat Chagas disease since the decade of 70ies. Both drugs are effective in acute phase or recent chronic phase of the disease, but they can induce side effects for the patients. Therefore, more efficient drugs with lower toxicity are need for the treatment of this disease. Synthesis of transition metal compounds, especially ruthenium, has increased over the years and data have shown many biological applications of these compounds.
Keywords in Portuguese
Trypanosoma cruzi
Doença de Chagas
Droga
Compostos de rutênio
Animais
Camundongos
 
Keywords
Trypanosoma cruzi
Chagas disease
Drugs
Ruthenium compounds
Animals
Mice
 
Publisher
Sociedade Brasileira de Medicina Tropical
Citation
BASTOS, T. M. et al. Evaluation of anti-Trypanosoma cruzi activities of nitrosyl/nitro ruthenium complexes in vitro and in vivo. In: CONGRESSO INTERNACIONAL DE MEDICINA TROPICAL E MALÁRIA, 18 e CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 48., 2012, Rio de Janeiro. Resumos... Rio de Janeiro: Sociedade Brasileira de Medicina Tropical, 2012.