Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/23599
Title: C1q binding to dengue virus decreases levels of infection and inflammatory molecules transcription in THP-1 cells
Authors: Douradinha, Bruno
McBurney, Sean P.
Melo, Klecia M. Soares de
Smith, Amanda P.
Krishna, Neel K.
Barratt-Boyes, Simon M.
Evans, Jared D.
Nascimento, Eduardo J. M.
Marques, Ernesto T. A.
Affilliation: Fondazione Ri.MED. Palermo, Italy / University of Pittsburgh. Center for Vaccine Research. Pittsburgh, USA.
University of Pittsburgh. Center for Vaccine Research. Pittsburgh, USA.
University of Pittsburgh. Center for Vaccine Research. Pittsburgh, USA / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil.
University of Pittsburgh. Center for Vaccine Research. Pittsburgh, USA.
Eastern Virginia Medical School. Department of Microbiology and Molecular Cell Biology. Norfolk, Virginia, USA.
University of Pittsburgh. Center for Vaccine Research. Pittsburgh, USA / University of Pittsburgh. Graduate School of Public Health. Department of Infectious Diseases and Microbiology. Pittsburgh, USA.
University of Pittsburgh. Center for Vaccine Research. Pittsburgh, USA / University of Pittsburgh. School of Medicine. Department of Microbiology and Molecular Genetics. Pittsburgh, USA.
University of Pittsburgh. Center for Vaccine Research. Pittsburgh, USA / University of Pittsburgh. Graduate School of Public Health. Department of Infectious Diseases and Microbiology. Pittsburgh, USA.
University of Pittsburgh. Center for Vaccine Research. Pittsburgh, USA / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil / University of Pittsburgh. Graduate School of Public Health. Department of Infectious Diseases and Microbiology. Pittsburgh, USA.
Abstract: Dengue virus infection elicits a spectrum of clinical presentations ranging from asymptomatic to severe disease. The mechanisms leading to severe dengue are not known, however it has been reported that the complement system is hyper-activated in severe dengue. Screening of complement proteins demonstrated that C1q, a pattern recognition molecule, can bind directly to dengue virus envelope protein and to whole dengue virus serotype 2. Incubation of dengue virus serotype 2 with C1q prior to infection of THP-1 cells led to decreased virus infectivity and modulation of mRNA expression of immunoregulatory molecules suggesting reduced inflammatory responses.
Keywords: Dengue
Dengue Hemorrhagic Fever
Dengue Fever
C1q
Classical Complement Pathway
Viral Persistence
keywords: Dengue
Febre Hemorrágica da Dengue
Febre de Dengue
C1q
Caminho de Complemento Clássico
Persistência Viral
DeCS: Complemento C1q
metabolismo
Vírus da Dengue
fisiologia
Dengue
genética
Mediadores da Inflamação
imunologia
Antígenos CD14
genética
Antígenos CD14
imunologia
Antígenos CD86
genética
Antígenos CD86
imunologia
Moléculas de Adesão Celular
genética
Linhagem Celular
humanos
Complemento C1q
imunologia
Dengue
metabolismo
Dengue
virologia
Vírus da Dengue
classificação
Lectinas Tipo C
Ligação Proteica
Receptores de Superfície Celular
Proteínas do Envelope Viral
Issue Date: 2014
Publisher: Elsevier
Citation: DOURADINHA, B. et al. C1q binding to dengue virus decreases levels of infection and inflammatory molecules transcription in THP-1 cells. Virus Research, v. 179, p. 231–234, jan. 2014.
DOI: 10.1016/j.virusres.2013.11.007
ISSN: 1872-7492
Copyright: open access
Appears in Collections:PE - IAM - Artigos de Periódicos

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