| Author | Meira, Cássio Santana | |
| Author | Guimarães, Elisalva Teixeira | |
| Author | Moreira, Diogo Rodrigo de Magalhães | |
| Author | Leite, Ana Cristina Lima | |
| Author | Pereira, Valeria Rego Alves | |
| Author | Melo, C. M. L | |
| Author | Neves, Juliana Kelle de Andrade Lemoine | |
| Author | Soares, Milena Botelho Pereira | |
| Access date | 2017-12-12T16:42:16Z | |
| Available date | 2017-12-12T16:42:16Z | |
| Document date | 2012 | |
| Citation | MEIRA, C. S. et al. 2-Iminothiazolidin-4-ones arrest Trypanosoma cruzi growth and impair trypomastigote development in macrophages. In: CONGRESSO INTERNACIONAL DE MEDICINA TROPICAL E MALÁRIA, 18 e CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 48., 2012, Rio de Janeiro. Resumos... Rio de Janeiro: Sociedade Brasileira de Medicina Tropical, 2012 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/23623 | |
| Language | eng | pt_BR |
| Publisher | Sociedade Brasileira de Medicina Tropical | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Doença de Chagas | pt_BR |
| Subject in Portuguese | Quimioterapia | pt_BR |
| Subject in Portuguese | Macrófagos | pt_BR |
| Subject in Portuguese | Infecção | pt_BR |
| Subject in Portuguese | Animais | pt_BR |
| Subject in Portuguese | Camundongos | pt_BR |
| Title | 2-Iminothiazolidin-4-ones arrest Trypanosoma cruzi growth and impair trypomastigote development in macrophages | pt_BR |
| Type | Papers presented at events | pt_BR |
| Abstract | Chagas disease, caused by the flagellate protozoan Trypanosoma cruzi, affects about 18 million people in
the Americas. Current chemotherapy of Chagas disease is based on benznidazole, which is toxic and has
limited efficacy. Therefore, new chemotherapeutic agents need to be developed. In this work, we describe
the identification of eight Trypanosoma cruzi inhibitors through a combination of thiazoles and
hydrazones chemistry. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Pernambuco. Department of Pharmaceutical Sciences. Recife, PE, Brazil | pt_BR |
| Affilliation | Federal University of Pernambuco. Department of Pharmaceutical Sciences. Recife, PE, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center of Biotechnology and Cell Therapy. Salvador, BA, Brasil | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| Subject | Chagas disease | pt_BR |
| Subject | Chemotherapy | pt_BR |
| Subject | Macrophages | pt_BR |
| Subject | Infection | pt_BR |
| Subject | Animals | pt_BR |
| Subject | Mice | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
