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2-IMINOTHIAZOLIDIN-4-ONES ARREST TRYPANOSOMA CRUZI GROWTH AND IMPAIR TRYPOMASTIGOTE DEVELOPMENT IN MACROPHAGES
Meira, Cássio Santana et al. | Date Issued: 2012
Author
Meira, Cássio Santana
Guimarães, Elisalva Teixeira
Moreira, Diogo Rodrigo de Magalhães
Leite, Ana Cristina Lima
Pereira, Valeria Rego Alves
Melo, C. M. L
Neves, Juliana Kelle de Andrade Lemoine
Soares, Milena Botelho Pereira
Affilliation
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Pernambuco. Department of Pharmaceutical Sciences. Recife, PE, Brazil
Federal University of Pernambuco. Department of Pharmaceutical Sciences. Recife, PE, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center of Biotechnology and Cell Therapy. Salvador, BA, Brasil
Abstract
Chagas disease, caused by the flagellate protozoan Trypanosoma cruzi, affects about 18 million people in the Americas. Current chemotherapy of Chagas disease is based on benznidazole, which is toxic and has limited efficacy. Therefore, new chemotherapeutic agents need to be developed. In this work, we describe the identification of eight Trypanosoma cruzi inhibitors through a combination of thiazoles and hydrazones chemistry.
Keywords in Portuguese
Trypanosoma cruzi
Doença de Chagas
Quimioterapia
Macrófagos
Infecção
Animais
Camundongos
 
Keywords
Trypanosoma cruzi
Chagas disease
Chemotherapy
Macrophages
Infection
Animals
Mice
 
Publisher
Sociedade Brasileira de Medicina Tropical
Citation
MEIRA, C. S. et al. 2-Iminothiazolidin-4-ones arrest Trypanosoma cruzi growth and impair trypomastigote development in macrophages. In: CONGRESSO INTERNACIONAL DE MEDICINA TROPICAL E MALÁRIA, 18 e CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 48., 2012, Rio de Janeiro. Resumos... Rio de Janeiro: Sociedade Brasileira de Medicina Tropical, 2012