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https://www.arca.fiocruz.br/handle/icict/23623| Title: | 2-Iminothiazolidin-4-ones arrest Trypanosoma cruzi growth and impair trypomastigote development in macrophages |
| Authors: | Meira, Cássio Santana Guimarães, Elisalva Teixeira Moreira, Diogo Rodrigo de Magalhães Leite, Ana Cristina Lima Pereira, Valeria Rego Alves Melo, C. M. L Neves, Juliana Kelle de Andrade Lemoine Soares, Milena Botelho Pereira |
| Affilliation: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil Federal University of Pernambuco. Department of Pharmaceutical Sciences. Recife, PE, Brazil Federal University of Pernambuco. Department of Pharmaceutical Sciences. Recife, PE, Brazil Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, Brasil Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, Brasil Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, Brasil Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center of Biotechnology and Cell Therapy. Salvador, BA, Brasil |
| Abstract: | Chagas disease, caused by the flagellate protozoan Trypanosoma cruzi, affects about 18 million people in the Americas. Current chemotherapy of Chagas disease is based on benznidazole, which is toxic and has limited efficacy. Therefore, new chemotherapeutic agents need to be developed. In this work, we describe the identification of eight Trypanosoma cruzi inhibitors through a combination of thiazoles and hydrazones chemistry. |
| Keywords: | Trypanosoma cruzi Chagas disease Chemotherapy Macrophages Infection Animals Mice |
| keywords: | Trypanosoma cruzi Doença de Chagas Quimioterapia Macrófagos Infecção Animais Camundongos |
| Issue Date: | 2012 |
| Publisher: | Sociedade Brasileira de Medicina Tropical |
| Citation: | MEIRA, C. S. et al. 2-Iminothiazolidin-4-ones arrest Trypanosoma cruzi growth and impair trypomastigote development in macrophages. In: Congresso Internacional de Medicina Tropical e Malária, 18 e Congresso da Sociedade Brasileira de Medicina Tropical, 48., 2012, Rio de Janeiro. Resumos... Rio de Janeiro: Sociedade Brasileira de Medicina Tropical, 2012 |
| Copyright: | open access |
| Appears in Collections: | BA - IGM - Trabalhos Apresentados em Eventos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Chagas112 Meira CS SBMT 2012.pdf | 84.56 kB | Adobe PDF | View/Open |
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