Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/23632
Title: HLA-B∗44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population
Authors: Alencar, Liciana Xavier Eurico de
Braga-Neto, Ulisses de Mendonça
Nascimento, Eduardo José Moura do
Cordeiro, Marli Tenório
Silva, Ana Maria
Brito, Carlos Alexandre Antunes de
Silva, Maria da Paz Carvalho da
Gil, Laura Helena Vega Gonzales
Montenegro, Silvia Maria Lucena
Marques, Ernesto Torres de Azevedo
Affilliation: Fundaçao Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil.
Texas A&M University. Station College Station. Department of Electrical Engineering. Texas, USA.
University of Pittsburgh. Center for Vaccine Research. Department of Infectious Diseases and Microbiology. Pittsburgh, PA, USA.
Fundaçao Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil / Secretaria de Saúde do Estado de Pernambuco. Central Laboratory of Public Health. Recife, PE, Brazil.
Fundaçao Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil.
Universidade Federal de Pernambuco. Hospital das Clínicas. Clínica Médica. Recife, PE, Brazil.
Universidade Federal de Pernambuco. Centro de Ciências Biológicas. Departamento de Bioquímica e Biofísica. Recife, PE, Brazil.
Fundaçao Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de imunologia. Recife, PE, Brasil.
Fundaçao Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil / University of Pittsburgh. Center for Vaccine Research. Department of Infectious Diseases and Microbiology. Pittsburgh, PA, USA.
Abstract: Human leukocyte antigen (HLA) alleles have been correlated with susceptibility or resistance to severe dengue; however, few immunogenetic studies have been performed in Latin American (LA) populations. We have conducted immunogenetic studies of HLA class I and II alleles in a cohort of 187 patients with DENV-3 infection and confirmed clinical diagnosis of either severe dengue, known as dengue hemorrhagic fever (DHF), or the less severe form, dengue fever (DF), in Recife, Pernambuco, Brazil. An association analysis was performed using Fisher's association test, with odds ratios (ORs) calculated using conditional maximum likelihood estimates. HLA-B∗44 (P = 0.047, OR = 2.025, 95% CI = 0.97-4.24) was found to be associated with increased susceptibility to DHF in response to DENV-3 infection. In addition, HLA-B∗07 (P = 0.048, OR = 0.501, one-sided 95% CI = 0-0.99) and HLA-DR∗13 (P = 0.028, OR = 0.511, one-sided 95% CI = 0-0.91) were found to be associated with resistance to secondary dengue infection by DENV-3. These results suggest that HLA-B∗44 supertype alleles and their respective T-cell responses might be involved in susceptibility to severe dengue infections, whereas the HLA-B∗07 supertype alleles and DR∗13 might be involved in cross-dengue serotype immunity.
Keywords: Dengue
Brazil
epidemiology
Endemic Diseases, prevention & control
keywords: Dengue
Brasil
epidemiologia
Doenças Endêmicas, prevenção & controle.
DeCS: estudos transversais
Vírus da dengue
Dengue
prevenção & controle
Infecção por Vírus da Dengue
Humanos
Vírus da Dengue
genética
Vírus da Dengue
virologia
Brasil
epidemiologia
Dengue Grave
complicações
Vírus da Dengue
classificação
DNA
Feminino
Masculino
Índice de Gravidade de Doença
Dengue Grave
diagnóstico
Issue Date: 2013
Publisher: Jean-Paul Gonzalez
Citation: ALENCAR, L. Xavier Eurico de et al. HLA-B∗44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population. Journal of Tropical Medicine, v. 2013, p. 648475, 2013.
DOI: 10.1155/2013/648475
ISSN: 1687-9686
Copyright: open access
Appears in Collections:PE - IAM - Artigos de Periódicos

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