Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/23655
Title: Exaggerated blood pressure response during the exercise treadmill test as a risk factor for hypertension
Authors: Lima, S. G.
Albuquerque, M. F. P. M.
Oliveira, J. R. M.
Ayres, C. F. J.
Cunha, J. E. G.
Oliveira, D. F.
Lemos, R. R.
Souza, M. B. R.
Barbosa e Silva, O.
Affilliation: Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Saúde Coletiva. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Saúde Coletiva. Recife, PE, Brasil.
Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Recife, PE, Brasil.
Fundaçao Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Entomologia. Recife, PE, Brasil.
Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Recife, PE, Brasil.
Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Recife, PE, Brasil.
Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Recife, PE, Brasil.
Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Recife, PE, Brasil.
Universidade Federal de Pernambuco. Laboratório de Ergometria. Recife, PE, Brasil.
Abstract: Exaggerated blood pressure response (EBPR) during the exercise treadmill test (ETT) has been considered to be a risk factor for hypertension. The relationship of polymorphisms of the renin-angiotensin system gene with hypertension has not been established. Our objective was to evaluate whether EBPR during exercise is a clinical marker for hypertension. The study concerned a historical cohort of normotensive individuals. The exposed individuals were those who presented EBPR. At the end of the observation period (41.7 months = 3.5 years), the development of hypertension was analyzed within the two groups. Genetic polymorphisms and blood pressure behavior were assessed as independent variables, together with the classical risk factors for hypertension. The I/D gene polymorphism of the angiotensin-converting enzyme and M235T of angiotensinogen were ruled out as risk factors for hypertension. EBPR during ETT is not an independent influence on the chances of developing hypertension. No differences were observed between the hypertensive and normotensive individuals regarding gender (P = 0.655), skin color (P = 0.636), family history of hypertension (P = 0.225), diabetes mellitus (P = 0.285), or hypertriglyceridemia (P = 0.734). The risk of developing hypertension increased with increasing body mass index (BMI) and advancing age. The risk factors, which independently influenced the development of hypertension, were age and BMI. EBPR did not constitute an independent risk factor for hypertension and is probably a preclinical phase in the spectrum of normotension and hypertension.
Keywords: Hypertension
Risk factors
Exaggerated blood pressure response
keywords: Hipertensão
Fatores de risco
Resposta exagerada à pressão sanguínea
DeCS: Adolescente
Adulto
Idoso
Feminino
Humanos
Masculino
Meia-Idade
Adulto Jovem
Pressão Sanguínea
fisiologia
Hipertensão
fisiopatologia
Fatores Etários
Índice de Massa Corporal
Angiotensinogênio
genética
Pressão Sanguínea
genética
Estudos de Coortes
Teste de Esforço
Hipertensão
enzimologia
Hipertensão
genética
Peptidil Dipeptidase A
genética
Polimorfismo Genético
Estudos Retrospectivos
Fatores de Risco
Issue Date: 2013
Citation: LIMA, S. G. et al. Exaggerated blood pressure response during the exercise treadmill test as a risk factor for hypertension. Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas, v. 46, n. 4, p. 368–347, abr. 2013.
DOI: 10.1590/1414-431X20132830
ISSN: 1414-431X
Copyright: open access
Appears in Collections:PE - IAM - Artigos de Periódicos

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