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SNP TYPING REVEALS SIMILARITY IN MYCOBACTERIUM TUBERCULOSIS GENETIC DIVERSITY IN PORTUGAL AND NORTHEAST BRAZIL
Lopes, Joao Sollari Allegro Machado et al. | Date Issued: 2012
Author
Lopes, Joao Sollari Allegro Machado
Marques, I
Soares, Patricia
Guimaraes, H
Costa, J
Miranda, A
Alves, A
Macedo, R
Antunes, A. F
Duarte, Tonya Azevedo
Barbosa, Theolis Costa
Nery, Joilda Silva
Boechat, Neio
Pereira, Susan Martins
Barreto, Maurício Lima
Leal, J. Pereira
Gomes, Maria Gabriela Miranda
Penha, Goncalves C
Affilliation
Instituto Gulbenkian de Ciencia. Oeiras, Portugal
Instituto Gulbenkian de Ciencia. Oeiras, Portugal
Instituto Gulbenkian de Ciencia. Oeiras, Portugal
Instituto Gulbenkian de Ciencia. Oeiras, Portugal
Instituto Gulbenkian de Ciencia. Oeiras, Portugal
Instituto Nacional de Saude Dr. Ricardo Jorge. Porto, Portugal
Instituto Nacional de Saude Dr. Ricardo Jorge. Porto, Portugal
Direccao Geral da Saude. Lisboa, Portugal
Direccao Geral da Saude. Lisboa, Portugal
Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil
Universidade Federal da Bahia. Salvador, BA, Brasil
Universidade Federal da Bahia. Salvador, BA, Brasil
Instituto Gulbenkian de Ciencia. Oeiras, Portugal
Instituto Gulbenkian de Ciencia. Oeiras, Portugal
Instituto Gulbenkian de Ciencia. Oeiras, Portugal
Abstract
Introduction: Human tuberculosis is an infectious disease primarily caused by Mycobacterium tuberculosis (Mtb). At the moment, the gold standard of epidemiological genotyping of Mtb is Spoligtyping and MIRU-VNTR. These markers, however, have limited use for phylogenetics and strain identification since their fast substitution rate leads to convergent evolution. Recent studies have introduced the use of single nucleotide polymorphisms (SNP) data for identification of Mtb strain groups. In this work we use SNP typing techniques to characterize and compare Mtb populations from Portugal and Brazil. We complement this analysis by discussing the benefits and caveats of this technique.
Keywords in Portuguese
Mycobacterium tuberculosis
Polimorfismo de nucleotídeo único
Genética
Brasil
Portugal
 
Keywords
Mycobacterium tuberculosis
Single nucleotide polymorphisms
Genetic
Brazil
Portugal
 
Publisher
Sociedade Brasileira de Medicina Tropical
Citation
LOPES, J. S. A. M. et al. SNP typing reveals similarity in Mycobacterium tuberculosis genetic diversity in Portugal and Northeast Brazil. In: CONGRESSO INTERNACIONAL DE MEDICINA TROPICAL E MALÁRIA, 18 e CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 48., 2012, Rio de Janeiro. Resumos... Rio de Janeiro: Sociedade Brasileira de Medicina Tropical, 2012.