Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/23786
Title: Mutations in SOD-1 gene are associated with different protein expression and susceptibility to malaria
Authors: Mendonça, Vitor Rosa Ramos de
Andrade, Bruno de Bezerril
Souza, Ligia Correia Lima de
Garcia, Gabriela Barreto Caldas
Queiroz, Artur Trancoso Lopo
Gonçalves, Marilda de Souza
Barral Netto, Manoel
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
National Institute of Allergy and Infectious Diseases National Institutes of Health. Laboratory of Parasitic Diseases,Immunobiology Section. Bethesda, MD, United States of America
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia. São Paulo, SP, Brasil.
Abstract: Introduction: During malaria, intense inflammation results in oxidative stress, and superoxide anions are the main reactive oxygen species produced. Cu/Zn superoxide dismutase (SOD1) is a key enzyme that, in together with catalase and glutathione peroxidase, scavenges superoxide anions and protects cells from oxidative damage. We have previously shown that SOD1 plasma levels are elevated in vivax malaria and that this enzyme can be used as a reliable biomarker for severe disease. Here, we test whether mutations in SOD1 gene (exon 1) and a Single Nucleotide Polymorphism (SNP) -308 (G>A) in the TNFalpha gene are associated with susceptibility to vivax malaria.
Keywords: Malaria
Mutation
Gene
Plasma volume
Protein
keywords: Malaria
Mutações
Gene
Volume plasmático
Proteinas
Issue Date: 2012
Publisher: Sociedade Brasileira de Medicina Tropical
Citation: MENDONÇA, V. R. R. M. et al. Mutations in SOD-1 gene are associated with different protein expression and susceptibility to malaria. In: Congresso Internacional de Medicina Tropical e Malária, 18 e Congresso da Sociedade Brasileira de Medicina Tropical, 48., 2012, Rio de Janeiro. Resumos... Rio de Janeiro: Sociedade Brasileira de Medicina Tropical, 2012.
Copyright: open access
Appears in Collections:BA - IGM - Trabalhos Apresentados em Eventos

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