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MOLECULAR CHARACTERIZATION OF NEISSERIA MENINGITIDIS ISOLATES RECOVERED FROM 11 TO 19 YEAR-OLD MENINGOCOCCAL CARRIERS IN SALVADOR, BRAZIL
Moura, Ana Rafaela Silva Simões et al. | Date Issued: 2012
Author
Moura, Ana Rafaela Silva Simões
Kretz, C
Ferreira, I. E
Nunes, Amelia Maria Pithon Borges Nunes
Moraes, José Cassio de
Reis, Mitermayer Galvão dos
McBride, Alan John Alexander
Wang, X
Campos, Leila Carvalho
Affilliation
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Centers for Disease Control and Prevention. Meningitis and Vaccine Preventable Diseases Branch. Division of Bacterial Diseases. Atlanta, United States of America
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Faculdade de Ciências Médicas da Santa Casa de São Paulo. São Paulo, SP, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Universidade Federal de Pelotas. Centro de Desenvolvimento Tecnológico, Núcleo de Biotecnologia. Pelotas, RGS, Brasil
Centers for Disease Control and Prevention. Meningitis and Vaccine Preventable Diseases Branch. Division of Bacterial Diseases. Atlanta, United States of America
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Abstract
The meningococcal population is very genetically and antigenically diverse due to the genome plasticity of N. meningitidis (Nm). This organism undergoes frequent horizontal gene transfer. Considering that isolates from carriers seems to be the principal source of virulence alleles and gene exchange, understanding the meningococcal population among carriers is of utmost importance for epidemiology and public health interventions. The aim of this study was to determine the molecular characteristics of Nm isolated from carriers in Salvador, Bahia, Brazil. In total, 59 meningococcal isolates were collected in a cross-sectional study of 11-19 year-old carriers living in Salvador, Brazil, in 2014.
Keywords in Portuguese
Neisseria meningitidis
Diversidade genética
Meningite meningococica
Genoma
Brasil
 
Keywords
Neisseria meningitidis
Genetical diversity
Meningococcal meningitidis
Genome
Brazil
 
Publisher
Sociedade Brasileira de Medicina Tropical
Citation
MOURA, A. R. S. S. et al. Molecular characterization of Neisseria Meningitidis isolates recovered from 11 to 19 year-old meningococcal carriers in Salvador, Brazil. In: Congresso INTERNACIONAL DE MEDICINA TROPICAL E MALÁRIA, 18 e CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 48., 2012, Rio de Janeiro. Resumos... Rio de Janeiro: Sociedade Brasileira de Medicina Tropical, 2012.