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Title: Dengue infection in pregnancy and its impact on the placenta
Authors: Ribeiro, Christiane Fernandes
Lopes, Vânia Glória Silami
Brasil, Patrícia
Pires, Andrea Rodrigues Cordovil
Rohloff, Roger
Nogueira, Rita Maria Ribeiro
Affilliation: Universidade Federal Fluminense. Departamento Materno-Infantil. Niterói, RJ, Brasil
Universidade Federal Fluminense. Departamento de Patologia. Niterói, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Perinatal Laranjeiras. Unidade de Cuidados Intensivos Materno-fetal. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivirus. Rio de Janeiro, RJ, Brasil.
Abstract: A histopathological and immunohistochemical study was conducted in placental tissues and retained products of conception from 24 patients with confirmed dengue infection during pregnancy. The immunohistochemical assay was positive for dengue virus in 19 placental and three ovular remnants analyzed. The light microscopic findings were signs of hypoxia, choriodeciduitis, deciduitis and intervillositis and the viral antigens were found in cytoplasmic of the trophoblast, villous stroma and decidua. Our results suggest that immunohistochemistry could be used as a laboratory confirmation method for dengue in pregnant women, especially in endemic areas when embedded material is the only material available.
Keywords: Dengue
Vertical transmission
keywords: Dengue
Transmissão vertical
Issue Date: 2017
Publisher: Elsevier
Citation: RIBEIRO, Christiane Fernandes; et al. Dengue infection in pregnancy and its impact on the placenta. International Journal of Infectious Diseases, v.55, p.109-112, 2017.
DOI: 10.1016/j.ijid.2017.01.002
ISSN: 1201-9712
Copyright: restricted access
Appears in Collections:INI - Artigos de Periódicos
IOC - Artigos de Periódicos

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