| Author | Buonora, Sibelle Nogueira | |
| Author | Santos, Flávia Barreto dos | |
| Author | Daumas, Regina Paiva | |
| Author | Passos, Sonia Regina Lambert | |
| Author | Silva, Manoela Heringer da | |
| Author | Lima, Monique Rocha de | |
| Author | Nogueira, Rita Maria Ribeiro | |
| Access date | 2018-02-20T11:23:49Z | |
| Available date | 2018-02-20T11:23:49Z | |
| Document date | 2017 | |
| Citation | BUONORA, Sibelle Nogueira; et al. Increased sensitivity of NS1 ELISA by heat dissociation in acute dengue 4 cases. BMC Infectious Diseases, v.17:204, 5p, 2017. | pt_BR |
| ISSN | 1471-2334 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/24871 | |
| Language | eng | pt_BR |
| Publisher | BioMed Central | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Ensaio de Imunoadsorção Enzimática | pt_BR |
| Subject in Portuguese | Precisão | pt_BR |
| Subject in Portuguese | Diagnóstico de Dengue | pt_BR |
| Subject in Portuguese | Dissociação do complexo imunitário | pt_BR |
| Title | Increased sensitivity of NS1 ELISA by heat dissociation in acute dengue 4 cases | pt_BR |
| Type | Article | |
| DOI | 10.1186/s12879-017-2306-z | |
| Abstract | Dengue is an acute febrile illness considered the major arboviral disease in terms of morbidity, mortality, economic impact and dissemination worldwide. Brazil accounts for the highest notification rate, with circulation of all four dengue serotypes. The NS1 antigen is a dengue highly conserved specific soluble glycoprotein essential for viral replication and viability that can be detected 0 to 18 days from the onset of fever (peak first 3 days). It induces a strong humoral response and is known as a complement-fixing antigen. Lower NS1 test sensitivity occurs in secondary dengue infections probably due to immune complex formation impairing antigen detection by ELISA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivirus. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Centro de Saúde Escola Germano Sinval Faria. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivirus. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivirus. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivirus. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | NS1 ELISA | pt_BR |
| Subject | Accuracy | pt_BR |
| Subject | Dengue diagnosis | pt_BR |
| Subject | Immune complex dissociation | pt_BR |
| Subject | DENV-4 | pt_BR |
