Author | Alves, Iura Muniz | |
Author | Abreu, Lucas Silva | |
Author | Costa, Cinara Oliveira D' Souza | |
Author | Le Hyaric, Mireille | |
Author | Guedes, Maria Lenise Silva | |
Author | Soares, Milena Botelho Pereira | |
Author | Bezerra, Daniel Pereira | |
Author | Velozo, Eudes da Silva | |
Access date | 2018-02-21T13:10:07Z | |
Available date | 2018-02-21T13:10:07Z | |
Document date | 2017 | |
Citation | ALVES, I. M. et al. Pyranochromones from Dictyoloma vandellianum A. Juss and Their Cytotoxic Evaluation. Chemistry & Biodiversity, v. 14, e1600276, 2017. | pt_BR |
ISSN | 1612-1872 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/24897 | |
Sponsorship | CAPES and CNPq | pt_BR |
Language | eng | pt_BR |
Publisher | Wiley | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Chromones | pt_BR |
Subject in Portuguese | Limonoids | pt_BR |
Subject in Portuguese | Alcalóides | pt_BR |
Subject in Portuguese | Substâncias citotóxicas | pt_BR |
Subject in Portuguese | Dictyoloma | pt_BR |
Subject in Portuguese | Rutaceae | pt_BR |
Title | Pyranochromones from Dictyoloma vandellianum A. Juss and Their Cytotoxic Evaluation | pt_BR |
Type | Article | pt_BR |
DOI | 10.1002/cbdv.201600276 | |
Abstract | One new chromone 3,3-dimethylallylspatheliachromene methyl ether (1), as well as five known chromones, 6-(3-methylbut-2-enyl) allopteroxylin methyl ether (2), 6-(3-methylbut-2-enyl) allopteroxylin (3), 3,3-dimethylallylspatheliachromene (4), 5-O-methylcneorumchromone K (5) and spatheliabischromene (6), two alkaloids, 8-methoxy-N-methylflindersine (7) and 8-methoxyflindersine (8), and two limonoids, limonin diosphenol (9) and rutaevin (10), were isolated from Dictyoloma vandellianum A. Juss (Rutaceae). Cytotoxic activities towards tumor cell lines B16-F10, HepG2, K562 and HL60 and non-tumor cells PBMC were evaluated for compounds 1 - 6. Compound 1 was the most active showing IC50values ranging from 6.26 to 14.82 μg/ml in B16-F10 and K562 cell lines, respectively, and presented IC50value of 11.65 μg/ml in PBMC cell line. | pt_BR |
Affilliation | Federal University of Bahia. Institute of Chemistry. Salvador, BA, Brazil | pt_BR |
Affilliation | Federal University of Bahia. College of Pharmacy. Salvador, BA, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Juiz de Fora. Department of Chemistry. Juiz de Fora, MG, Brazil | pt_BR |
Affilliation | Federal University of Bahia. Institute of Biology. Salvador, BA, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. Institute of Chemistry. Salvador, BA, Brazil / Federal University of Bahia. College of Pharmacy. Salvador, BA, Brazil | pt_BR |
Subject | Chromones | pt_BR |
Subject | Limonoids | pt_BR |
Subject | Alkaloids | pt_BR |
Subject | Cytotoxic activities | pt_BR |
Subject | Dictyoloma | pt_BR |
Subject | Rutaceae | pt_BR |