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https://www.arca.fiocruz.br/handle/icict/24897
PYRANOCHROMONES FROM DICTYOLOMA VANDELLIANUM A. JUSS AND THEIR CYTOTOXIC EVALUATION
Author
Affilliation
Federal University of Bahia. Institute of Chemistry. Salvador, BA, Brazil
Federal University of Bahia. College of Pharmacy. Salvador, BA, Brazil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Juiz de Fora. Department of Chemistry. Juiz de Fora, MG, Brazil
Federal University of Bahia. Institute of Biology. Salvador, BA, Brazil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Bahia. Institute of Chemistry. Salvador, BA, Brazil / Federal University of Bahia. College of Pharmacy. Salvador, BA, Brazil
Federal University of Bahia. College of Pharmacy. Salvador, BA, Brazil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Juiz de Fora. Department of Chemistry. Juiz de Fora, MG, Brazil
Federal University of Bahia. Institute of Biology. Salvador, BA, Brazil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Bahia. Institute of Chemistry. Salvador, BA, Brazil / Federal University of Bahia. College of Pharmacy. Salvador, BA, Brazil
Abstract
One new chromone 3,3-dimethylallylspatheliachromene methyl ether (1), as well as five known chromones, 6-(3-methylbut-2-enyl) allopteroxylin methyl ether (2), 6-(3-methylbut-2-enyl) allopteroxylin (3), 3,3-dimethylallylspatheliachromene (4), 5-O-methylcneorumchromone K (5) and spatheliabischromene (6), two alkaloids, 8-methoxy-N-methylflindersine (7) and 8-methoxyflindersine (8), and two limonoids, limonin diosphenol (9) and rutaevin (10), were isolated from Dictyoloma vandellianum A. Juss (Rutaceae). Cytotoxic activities towards tumor cell lines B16-F10, HepG2, K562 and HL60 and non-tumor cells PBMC were evaluated for compounds 1 - 6. Compound 1 was the most active showing IC50values ranging from 6.26 to 14.82 μg/ml in B16-F10 and K562 cell lines, respectively, and presented IC50value of 11.65 μg/ml in PBMC cell line.
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