Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/24980
Title: Distribution of superantigens in group A streptococcal isolates from Salvador, Brazil
Authors: Berman, Hillary F
Tartof, Sara Yee
Reis, Joice N
Reis, Mitermayer Galvão dos
Riley, Lee W
Affilliation: University of California. School of Public Health. Division of Infectious Disease and Vaccinology. Berkeley, CA, USA
University of California. School of Public Health. Division of Infectious Disease and Vaccinology. Berkeley, CA, USA / Kaiser Permanente Southern California Research and Evaluation. Pasadena, CA, USA
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil
University of California. School of Public Health. Division of Infectious Disease and Vaccinology. Berkeley, CA, USA
Abstract: Group A streptococcus (GAS) causes invasive disease, superficial disease, and can asymptomatically colonize humans. Superantigens are one virulence factor found in GAS. Previous studies found associations between the genes that encode superantigens and emm type of GAS. It is unknown if these associations are due to underlying biological factors that limit the distribution of superantigens or, alternatively, if these associations are due to the expansion of local GAS linages where these studies took place. To further address this question we screened GAS isolates collected from Salvador, Brazil for 11 known superantigen genes. Methods: Seventy-seven GAS isolates were screened by PCR for superantigen genes. These superantigen genes were speA, speC, speG, speH, speI, speJ, speK, speL, speM, ssa, and smeZ. We used Fisher’s two-sided exact test to identify associations between superantigens and GAS emm type. We then compared our results to previous reports of superantigen prevalence and superantigen association with emm type. Results: In our collection we found several emm type and superantigen genotype combinations that have previously been reported in isolates from Europe and Australia. We also found that speA was significantly associated with emm type 1, and that speC was significantly associated with emm type 12. Conclusions: Our study reports superantigen genotypes of GAS from a region of the world that is lacking this information. We found evidence of common GAS superantigen genotypes that are spread worldwide as well as novel superantigen genotypes that, so far, are unique to Brazil.
Keywords: Streptococcus pyogenes
Streptococcal superantigens
Group A streptococcus
Emm types
keywords: Streptococcus pyogenes
Fagos estreptocócicos
Estreptococos
Issue Date: 2014
Publisher: BioMed Central
Citation: BERMAN, H. F. et al. Distribution of superantigens in group A streptococcal isolates from Salvador, Brazil. BMC Infectious Diseases, v. 14, p. 294, 2014.
DOI: 10.1186/1471-2334-14-294
ISSN: 1471-2334
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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