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EVALUATION OF IL-6 (-174 G/C) POLYMORPHISM IN ACUTE CORONARY SYNDROME IN THE NORTHEAST OF BRAZIL
Isquemia do miocárdio
Polimorfismo, genético
Interleucina-6
Myocardial Ischemia
Polymorphism, Genetic
Interleukin-6
Autor(es)
Afiliação
Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Laboratório de Imunopatologia e Biologia Molecular. Departamento de Imunologia. Recife, PE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Laboratório de Imunopatologia e Biologia Molecular. Departamento de Imunologia. Recife, PE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Laboratório de Imunopatologia e Biologia Molecular. Departamento de Imunologia. Recife, PE, Brasil
Real Hospital Português. Real Hospital do Coração. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Biologia Parasitária. Salvador, BA, Brasil
Universidade de Pernambuco. Faculdade de Ciências Médicas. Recife, PE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Laboratório de Imunopatologia e Biologia Molecular. Departamento de Imunologia. Recife, PE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Laboratório de Imunopatologia e Biologia Molecular. Departamento de Imunologia. Recife, PE, Brasil
Real Hospital Português. Real Hospital do Coração. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Biologia Parasitária. Salvador, BA, Brasil
Universidade de Pernambuco. Faculdade de Ciências Médicas. Recife, PE, Brasil
Resumo em Inglês
Background: Acute coronary syndrome (ACS) is a leading cause of morbidity and mortality worldwide. It is a
multifactorial disease caused by obstruction of the coronary arteries by atheromatous plaques and leads to heart
ischemia. Several studies suggest that some genetic polymorphisms change the cytokines levels and influence ACS
development.Objective: In this study, we evaluated the IL-6 (-174G/C) polymorphism, serum levels of cytokine and its
relationship with ACS and the thrombolysis in myocardial infarction (TIMI) risk score.
Materials and Methods: A sample of 200 patients with ACS [TIMI risk – Low (70); Intermediate (89); High (41)]
in Brazilian population was used. Genotyping was carried out by polymerase chain reaction, followed by DNA
sequencing.
Results: There was no significant differences in genotype (p = 0.53) and allele (p = 0.32) distributions between ACS
patient and without ACS patients groups on IL-6 allelic polymorphism and between the three differents TIMI risk
score (p > 0.05). Moreover IL-6 polymorphism did not affect the cytokine levels and these levels were not related
to TIMI score.
Conclusions: With these results, we suggest that the IL-6 (-174 G/C) polymorphism, until now, is not related to
ACS and did not change the levels of the cytokine in studied population. Further studies with different populations
should be done to verify those results. It is important to emphasize that, since ACS is a multifactorial disease, other
risk factors and other pro-inflammatory cytokines should be assessed to better understand this pathology.
Palavras-chave
Síndrome coronariana agudaIsquemia do miocárdio
Polimorfismo, genético
Interleucina-6
Palavras-chave em inglês
Acute Coronary SyndromeMyocardial Ischemia
Polymorphism, Genetic
Interleukin-6
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