Author | Lima, Michele Souza | |
Author | Carneiro, Alan Brito | |
Author | Padron, Thaís Souto | |
Author | Jurberg, José | |
Author | Silva Neto, Mário Alberto Cardoso | |
Author | Atella, Georgia Correa | |
Access date | 2018-03-01T17:38:32Z | |
Available date | 2018-03-01T17:38:32Z | |
Document date | 2018 | |
Citation | LIMA, Michele Souza; et al. Triatoma infestans relies on salivary lysophosphatidylcholine to enhance Trypanosoma cruzi transmission. Acta Tropica, v.178, p.68-72, 2018. | pt_BR |
ISSN | 0001-706X | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/25025 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Triatoma infestans | pt_BR |
Subject in Portuguese | Trypanosoma cruzi | pt_BR |
Subject in Portuguese | Parasitemia | pt_BR |
Subject in Portuguese | Doença de Chagas | pt_BR |
Title | Triatoma infestans relies on salivary lysophosphatidylcholine to enhance Trypanosoma cruzi transmission | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.actatropica.2017.10.022 | |
Abstract | Triatoma infestans is a mandatory haematophagous vector of Chagas disease in Brazil. Despite a large number of studies on the anti-haemostatic molecules present in its saliva, the role of its salivary components on parasite transmission is poorly understood. Here, we show that the bioactive lipid molecule, lysophosphatidylcholine (LPC), is present in the salivary gland of T. infestans. We characterized the lipid profiles of each unit of the T. infestans salivary gland. We noticed that LPC is present in the three units of the salivary gland and that the insect feeding state does not influence its proportion. T. infestans saliva and LPC can enhance T. cruzi transmission to mice by dramatically altering the profile of inflammatory cells at the site of inoculation on mouse skin, facilitating the transmission of T. cruzi to the vertebrate host. Consequently, the mortality curves of either saliva- or LPC-injected mice display significant higher mortality rates than the control. Altogether, these results implicate LPC as one of key salivary molecule involved in Chagas disease transmission. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis, Programa de Biologia Estrutural. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Rogério Góes. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Referência Nacional e Internacional de Triatomíneos. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis, Programa de Biologia Estrutural. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis, Programa de Biologia Estrutural. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Triatoma infestans | pt_BR |
Subject | Lysophosphatidylcholine | pt_BR |
Subject | Parasitemia | pt_BR |
Subject | Trypanosoma cruzi | pt_BR |
Subject | Chagas Disease | pt_BR |
e-ISSN | 1873-6254 | |
Embargo date | 2030-01-01 | |