Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/25025
Title: Triatoma infestans relies on salivary lysophosphatidylcholine to enhance Trypanosoma cruzi transmission
Authors: Lima, Michele Souza
Carneiro, Alan Brito
Padron, Thaís Souto
Jurberg, José
Silva Neto, Mário Alberto Cardoso
Atella, Georgia Correa
Affilliation: Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis, Programa de Biologia Estrutural. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Rogério Góes. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Referência Nacional e Internacional de Triatomíneos. Rio de Janeiro, RJ, Brasil
Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis, Programa de Biologia Estrutural. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis, Programa de Biologia Estrutural. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular. Rio de Janeiro, RJ, Brasil.
Abstract: Triatoma infestans is a mandatory haematophagous vector of Chagas disease in Brazil. Despite a large number of studies on the anti-haemostatic molecules present in its saliva, the role of its salivary components on parasite transmission is poorly understood. Here, we show that the bioactive lipid molecule, lysophosphatidylcholine (LPC), is present in the salivary gland of T. infestans. We characterized the lipid profiles of each unit of the T. infestans salivary gland. We noticed that LPC is present in the three units of the salivary gland and that the insect feeding state does not influence its proportion. T. infestans saliva and LPC can enhance T. cruzi transmission to mice by dramatically altering the profile of inflammatory cells at the site of inoculation on mouse skin, facilitating the transmission of T. cruzi to the vertebrate host. Consequently, the mortality curves of either saliva- or LPC-injected mice display significant higher mortality rates than the control. Altogether, these results implicate LPC as one of key salivary molecule involved in Chagas disease transmission.
Keywords: Triatoma infestans
Lysophosphatidylcholine
Parasitemia
Trypanosoma cruzi
Chagas Disease
keywords: Triatoma infestans
Trypanosoma cruzi
Parasitemia
Doença de Chagas
Issue Date: 2018
Publisher: Elsevier
Citation: LIMA, Michele Souza; et al. Triatoma infestans relies on salivary lysophosphatidylcholine to enhance Trypanosoma cruzi transmission. Acta Tropica, v.178, p.68-72, 2018.
DOI: 10.1016/j.actatropica.2017.10.022
ISSN: 0001-706X
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

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