Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/25046
Title: Dissemination of the ST-103 clonal complex serogroup C meningococci in Salvador, Brazil
Authors: Cordeiro, Soraia Machado
Cardoso, Cristiane Wanderley
Araújo, Lorena Galvão de
Ribeiro, Luis Eduardo
Azevedo, Jailton
Silva, Rita de Cassia Vilasboas
Reis, Mitermayer Galvão dos
Ko, Albert Icksang
Reis, Joice Neves
Affilliation: Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. School of Pharmacy. Salvador, BA, Brazil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Municipal Secretary of Health of Salvador. Salvador, BA, Brazil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Bahia. School of Pharmacy. Salvador, BA, Brazil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil
Public Health Central Laboratory. Salvador, BA, Brazil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. School of Pharmacy. Salvador, BA, Brazil
Abstract: Invasive meningococcal disease (IMD) is a major public health problem worldwide. An epidemic of serogroup C (NmC) IMD occurred in 2010 in the city of Salvador. In this study, we describe the antigenic and genetic characterization of meningococcal isolates collected from meningitis cases in Salvador from 2001 to 2012. Pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST) were performed for the analysis of IMD isolates. A total of 733 cases were identified, and the serogroup was determined for 391 (53.0%) of these. Most cases were caused by NmC (53%) or B (47%). The most prevalent strains were B:4,7:P1.19,15 (32.9%; 129/391) and C:23:P1.14-6 (28.6%; 112/391). Based on PFGE/MLST analysis, 71.3% (77/108 PFGE-tested isolates) clustered as two clones of sequence type ST-3779 and ST-3780, both belonging to the ST-103 clonal complex. ST-3779 has been detected in Salvador since 1996 and together with ST-3780 became predominant after 2005. There was a predominance of C:23:P1.14-6, ST-3779/3780 in Salvador during the period of 2007-2012, establishing a major clonal lineage, which remained in the community for a long time; this has serious implications for public health, particularly in terms of prevention and control strategies of IMD.
Keywords: Meningococcal disease
Neisseria meningitidis
Meningococcal serogroup C
keywords: Doença meningocócica
Neisseria meningitidis
Meningite meningocócica
Issue Date: 2018
Publisher: Elsevier
Citation: CORDEIRO, S. M. et al. Dissemination of the ST-103 clonal complex serogroup C meningococci in Salvador, Brazil. Microbes and Infection, v. 20, p. 19-24, 2018.
DOI: 10.1016/j.micinf.2017.09.010
ISSN: 1286-4579
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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