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Title: Maternal-fetal transmission of the zika virus: An intriguing interplay
Authors: Zanluca, Camila
Noronha, Lucia de
Santos, Claudia Nunes Duarte dos
Affilliation: Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.
Pontifícia Universidade Católica do Paraná. Laboratório de Patologia Experimental, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.
Abstract: In this review, we give an overview of aspects related to the congenital transmission of the Zika virus (ZIKV). Although we acknowledge that important advances in research on ZIKV pathogenesis have come from studies using animal models, particularly non-human primates, this review emphasizes studies using ex-vivo human cells and tissues as well as natural infections in pregnant women. The possible routes used by ZIKV to cross or breach the placental barrier and infect the fetal central nervous system are presented. Understanding the viral infection biology and ZIKV pathogenesis during pregnancy may guide the design of affordable antiviral strategies to benefit pregnant women in areas at risk.
Keywords: Hofbauer cells
Zika Virus
Placental Barriers
Maternal-Fetal Transmission
Natural Infections
Ex Vivo Models
Issue Date: 2018
Publisher: Taylor & Francis
Citation: ZANLUCA, Camila; NORONHA, Lucia de; SANTOS, Claudia Nunes dos. Maternal-fetal transmission of the zika virus: an intriguing interplay. Tissue Barriers, v.6, n.1, p. 1-31, 2018.
DOI: 10.1080/21688370.2017.1402143
Copyright: restricted access
Revised document: Sim
Publication status: Publicado
Appears in Collections:PR - ICC - Preprint

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