| Author | Oliveira, Lorena Vivien Neves de | |
| Author | Costa, Marliete Carvalho | |
| Author | Magalhães, Thaís Furtado Ferreira | |
| Author | Bastos, Rafael Wesley | |
| Author | Santos, Patrícia C. | |
| Author | Carneiro, Hellem C. S. | |
| Author | Ribeiro, Noelly de Queiroz | |
| Author | Ferreira, Gabriella Freitas | |
| Author | Ribeiro, Lucas S. | |
| Author | Gonçalves, Ana Paula de Faria | |
| Author | Fagundes, Caio Tavares | |
| Author | Xavier, Marcelo Antonio Pascoal | |
| Author | Djordjevic, Julianne T. | |
| Author | Sorrell, Tania C. | |
| Author | Souza, Daniele da Gloria | |
| Author | Machado, Alexandre de Magalhães Vieira | |
| Author | Santos, Daniel de Assis | |
| Access date | 2018-03-15T16:13:47Z | |
| Available date | 2018-03-15T16:13:47Z | |
| Document date | 2017 | |
| Citation | OLIVEIRA, Lorena Vivien Neves de et al. Influenza A Virus as a Predisposing Factor for Cryptococcosis. Front Cell Infect Microbiol. , v. 7, p. 419, 2017. | pt_BR |
| ISSN | 2235-2988 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/25321 | |
| Language | eng | pt_BR |
| Publisher | Frontiers Media | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Criptococose | pt_BR |
| Subject in Portuguese | Cryptococcus gattii | pt_BR |
| Subject in Portuguese | influenza A H1N1 | pt_BR |
| Subject in Portuguese | co-incfecção | pt_BR |
| Subject in Portuguese | fator de risco | pt_BR |
| Title | Influenza A Virus as a Predisposing Factor for Cryptococcosis | pt_BR |
| Type | Article | |
| DOI | 10.3389/fcimb.2017.00419 | |
| Abstract | Influenza A virus (IAV) infects millions of people annually and predisposes to secondary bacterial infections. Inhalation of fungi within the Cryptococcus complex causes pulmonary disease with secondary meningo-encephalitis. Underlying pulmonary disease is a strong risk factor for development of C. gattii cryptococcosis though the effect of concurrent infection with IAV has not been studied. We developed an in vivo model of Influenza A H1N1 and C. gattii co-infection. Co-infection resulted in a major increase in morbidity and mortality, with severe lung damage and a high brain fungal burden when mice were infected in the acute phase of influenza multiplication. Furthermore, IAV alters the host response to C. gattii, leading to recruitment of significantly more neutrophils and macrophages into the lungs. Moreover, IAV induced the production of type 1 interferons (IFN-a4/b) and the levels of IFN-g were significantly reduced, which can be associated with impairment of the immune response to Cryptococcus during co-infection. Phagocytosis, killing of cryptococci and production of reactive oxygen species (ROS) by IAV-infected macrophages were reduced, independent of previous IFN-g stimulation, leading to increased proliferation of the fungus within macrophages. In conclusion, IAV infection is a predisposing factor for severe disease and adverse outcomes in mice co-infected with C. gattii. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Micologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Micologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Micologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Micologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Interação Micro-organismo Hospedeiro. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Micologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Juiz de Fora. Departamento de Farmácia. Governador Valadares, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Interação Micro-organismo Hospedeiro. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz Instituto René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Interação Micro-organismo Hospedeiro. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Centro de Pesquisa e Desenvolvimento de Fármacos. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz Instituto René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | University of Sydney and Westmead Institute for Medical Research. Marie Bashir Institute for Infectious Diseases and Biosecurity. Westmead, NSW, Australia | pt_BR |
| Affilliation | University of Sydney and Westmead Institute for Medical Research. Marie Bashir Institute for Infectious Diseases and Biosecurity. Westmead, NSW, Australia | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Interação Micro-organismo Hospedeiro. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz Instituto René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Micologia. Belo Horizonte, MG, Brazil | pt_BR |
| Subject | Cryptococcosis | pt_BR |
| Subject | Cryptococcus gattii | pt_BR |
| Subject | influenza A H1N1 | pt_BR |
| Subject | co-infection | pt_BR |
| Subject | risk factor | pt_BR |
| Embargo date | 2024-01-01 | |
