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Sustainable Development Goals
03 Saúde e Bem-EstarCollections
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ASSOCIATION BETWEEN PERIODONTITIS AND SEVERE ASTHMA IN ADULTS: A CASE-CONTROL STUDY
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Abstract
To evaluate the association between periodontitis and severe asthma, with participants in treatment for severe asthma, controlled by therapy. Methods: A case–control investigation was performed to compare 130 adults with
severe asthma with 130 without asthma. Individuals with periodontitis were those
with ≥4 teeth with ≥1 site with probing depth ≥4 mm, clinical attachment level ≥3 mm,
and bleeding upon probing at the same site. Severe asthma diagnosis was based on
Global Initiative for Asthma criteria.
Results: Association between exposure to periodontitis and severe asthma was found:
ORcrude = 2.98 (95% CI: 1.74–5.11). When confounders were considered, the association
between exposure to periodontitis and severe asthma was maintained:
ORadjusted = 3.01–3.25. Individuals with periodontitis had about a threefold increased
risk of severe asthma than those without periodontitis. Frequency of periodontitis in
participants with severe asthma was greater than that of those without asthma (46.6%
vs 22.3%, p ≤ .05).
Conclusions: Association between periodontitis and severe asthma was observed.
Further investigation is required to determine the direction of this relationship. It may
be causal, but it may also be a consequence of the immunopathological process that
characterizes asthma, or else, consequence of the medication used for treatment.
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