| Author | Mengel, Jose | |
| Author | Cardillo, Fabíola | |
| Access date | 2018-03-20T13:11:33Z | |
| Available date | 2018-03-20T13:11:33Z | |
| Document date | 2017 | |
| Citation | MENGEL, J.; CARDILLO, F. The Interleukin-17 (IL-17) Puzzle in Chagas’ Disease. Cellular Immunology and Serum Biology, v. 3, n. 2, p. 120-121, 2017. | pt_BR |
| ISSN | 2471-5891 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/25414 | |
| Language | eng | pt_BR |
| Publisher | Ommega Publishers | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Doença de Chagas | pt_BR |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Insuficiência cardíaca | pt_BR |
| Subject in Portuguese | Humanos | pt_BR |
| Subject in Portuguese | Infecção | pt_BR |
| Title | The Interleukin-17 (IL-17) Puzzle in Chagas’ Disease | pt_BR |
| Type | Article | pt_BR |
| Abstract | In this article, we discuss an alternative explanation for the fact that the production
and plasma levels of IL-17 are diminished in patients chronically infected with
Trypanosoma cruzi, suffering from congestive heart failure. This alternate hypothesis
considers the inhibitory pharmacological action of digoxin, a drug commonly used to
treat heart failure. We believe this is a significant point to be further studied as IL-17
was initially considered to be heart-protective. Therefore, our argument has profound
therapeutic implications | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil / Faculty of Medicine of Petrópolis. Petrópolis, RJ, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Subject | Chagas disease | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| Subject | Cardiac insufficiency | pt_BR |
| Subject | Humans | pt_BR |
| Subject | Infection | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
