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Title: The Interleukin-17 (IL-17) Puzzle in Chagas’ Disease
Authors: Mengel, Jose
Cardillo, Fabíola
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil / Faculty of Medicine of Petrópolis. Petrópolis, RJ, Brazil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil
Abstract: In this article, we discuss an alternative explanation for the fact that the production and plasma levels of IL-17 are diminished in patients chronically infected with Trypanosoma cruzi, suffering from congestive heart failure. This alternate hypothesis considers the inhibitory pharmacological action of digoxin, a drug commonly used to treat heart failure. We believe this is a significant point to be further studied as IL-17 was initially considered to be heart-protective. Therefore, our argument has profound therapeutic implications
Keywords: Chagas disease
Trypanosoma cruzi
Cardiac insufficiency
keywords: Doença de Chagas
Trypanosoma cruzi
Insuficiência cardíaca
Issue Date: 2017
Publisher: Ommega Publishers
Citation: MENGEL, J.; CARDILLO, F. The Interleukin-17 (IL-17) Puzzle in Chagas’ Disease. Cellular Immunology and Serum Biology, v. 3, n. 2, p. 120-121, 2017.
ISSN: 2471-5891
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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