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2018-12-31
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EFFECT OF IMMEDIATE INITIATION OF ANTIRETROVIRAL TREATMENT IN HIV-POSITIVE INDIVIDUALS AGED 50 YEARS OR OLDER
Antiretroviral treatment
CD4 Lymphocyte Count
Causal inference
Comparative Effectiveness Research
Author
Lodi, Sara
Costagliola, Dominique
Sabin, Caroline
Del Amo, Julia
Logan, Roger
Abgrall, Sophie
Reiss, Peter
van Sighem, Ard
Jose, Sophie
Blanco, Jose-Ramon
Hernando, Victoria
Bucher, Heiner C.
Kovari, Helen
Segura, Ferran
Ambrosioni, Juan
Gogos, Charalambos A.
Pantazis, Nikos
Dabis, Francois
Vandenhende, Marie-Anne
Meyer, Laurence
Seng, Rémonie
Gill, M John
Krentz, Hartmut
Phillips, Andrew N.
Porter, Kholoud
Grinsztejn, Beatriz
Pacheco, Antonio G.
Muga, Roberto
Tate, Janet
Justice, Amy
Hernán, Miguel A.
Costagliola, Dominique
Sabin, Caroline
Del Amo, Julia
Logan, Roger
Abgrall, Sophie
Reiss, Peter
van Sighem, Ard
Jose, Sophie
Blanco, Jose-Ramon
Hernando, Victoria
Bucher, Heiner C.
Kovari, Helen
Segura, Ferran
Ambrosioni, Juan
Gogos, Charalambos A.
Pantazis, Nikos
Dabis, Francois
Vandenhende, Marie-Anne
Meyer, Laurence
Seng, Rémonie
Gill, M John
Krentz, Hartmut
Phillips, Andrew N.
Porter, Kholoud
Grinsztejn, Beatriz
Pacheco, Antonio G.
Muga, Roberto
Tate, Janet
Justice, Amy
Hernán, Miguel A.
Affilliation
Harvard T.H. Chan School of Public Health. Department of Epidemiology. Boston.
Institut Pierre Louis d’épidémiologie et de Santé Publique. Sorbonne Universités, INSERM, UPMC Univ Paris 06. France.
Institute of Global Health.University College London. London, United Kingdom.
Instituto de Salud Carlos III. Centro Nacional de Epidemiologia. Madrid, Spain / Instituto de Salud Carlos III. CIBERESP. Madrid, Spain.
Harvard T.H. Chan School of Public Health. Department of Epidemiology. Boston.
Institut Pierre Louis d’épidémiologie et de Santé Publique. Sorbonne Universités, INSERM, UPMC Univ. Paris. Paris, France / Hôpital Antoine Béclère, Service de Médecine Interne. AP-HP, Clamart, France.
Stichting HIV Monitoring. Amsterdam, the Netherlands / Academic Medical Centre, Department of Global Health and Division of Infectious Diseases, University of Amsterdam, Amsterdam, the Netherlands / Amsterdam Institute for Global Health and Development, Amsterdam, the Netherlands.
Stichting HIV Monitoring. Amsterdam, the Netherlands.
Institute of Global Health.University College London. London, United Kingdom.
Hospital San Pedro—CIBIR, Logroño, Spain.
Instituto de Salud Carlos III. Centro Nacional de Epidemiologia. Madrid, Spain / Instituto de Salud Carlos III. CIBERESP. Madrid, Spain.
University of Basel. University Hospital Basel. Basel Institute for Clinical Epidemiology and Biostatistics, Basel, Switzerland.
University of Zurich. University Hospital Zurich. Division of Infectious Diseases and Hospital Epidemiology. Zurich, Switzerland.
Hospital Parc Tauli. Infectious Disease Department. Sabadell, Spain.
Hospital Clinic-IDIBAPS. Barcelona, Spain.
Patras University Hospital. Division of Infectious Diseases. Patras, Greece.
National and Kapodistrian University of Athens. Faculty of Medicine. Department of Hygiene, Epidemiology and Medical Statistics. Athens, Greece.
Université de Bordeaux, ISPED, Centre INSERM U1219-Epidemiologie-Biostatistique, Bordeaux, France / Université de Bordeaux. Centre INSERM U1219- Centre Inserm Epidémiologie et Biostatistique, Bordeaux, France.
Université de Bordeaux, ISPED, Centre INSERM U1219-Epidemiologie-Biostatistique, Bordeaux, France. / Université de Bordeaux. Centre INSERM U1219- Centre Inserm Epidémiologie et Biostatistique, Bordeaux, France / Bordeaux University Hospital. Department of Internal Medicine, Bordeaux, France.
Université Paris Sud, UMR 1018, le Kremlin Bicêtre, Paris, France / Inserm, UMR 1018, le Kremlin Bicêtre, Paris, France / AP-HP, Hôpital de Bicêtre, Service de Santé Publique, le Kremlin Bicêtre, Paris, France.
Inserm, UMR 1018, le Kremlin Bicêtre, Paris, France / AP-HP, Hôpital de Bicêtre, Service de Santé Publique, le Kremlin Bicêtre, Paris, France.
Southern Alberta Clinic, Calgary, AB, Canada / Department of Medicine, University of Calgary, Calgary, AB, Canada.
Southern Alberta Clinic, Calgary, AB, Canada / Department of Medicine, University of Calgary, Calgary, AB, Canada.
Instituto de Salud Carlos III. Centro Nacional de Epidemiologia. Madrid, Spain.
Instituto de Salud Carlos III. Centro Nacional de Epidemiologia. Madrid, Spain.
Fundacao Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Brasil.
Fundacao Oswaldo Cruz. Programa de Computação Científica, Rio de Janeiro, Brasil.
Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
Yale University School of Medicine. Department of Internal Medicine, New Haven.
Yale University School of Medicine. Department of Internal Medicine, New Haven / VA Connecticut Healthcare System, West Haven, CT.
Harvard T.H. Chan School of Public Health. Department of Epidemiology. Boston / Harvard T.H. Chan School of Public Health. Department of Biostatistics, Boston / Harvard-MIT Division of Health Sciences and Technology, Boston, MA.
Institut Pierre Louis d’épidémiologie et de Santé Publique. Sorbonne Universités, INSERM, UPMC Univ Paris 06. France.
Institute of Global Health.University College London. London, United Kingdom.
Instituto de Salud Carlos III. Centro Nacional de Epidemiologia. Madrid, Spain / Instituto de Salud Carlos III. CIBERESP. Madrid, Spain.
Harvard T.H. Chan School of Public Health. Department of Epidemiology. Boston.
Institut Pierre Louis d’épidémiologie et de Santé Publique. Sorbonne Universités, INSERM, UPMC Univ. Paris. Paris, France / Hôpital Antoine Béclère, Service de Médecine Interne. AP-HP, Clamart, France.
Stichting HIV Monitoring. Amsterdam, the Netherlands / Academic Medical Centre, Department of Global Health and Division of Infectious Diseases, University of Amsterdam, Amsterdam, the Netherlands / Amsterdam Institute for Global Health and Development, Amsterdam, the Netherlands.
Stichting HIV Monitoring. Amsterdam, the Netherlands.
Institute of Global Health.University College London. London, United Kingdom.
Hospital San Pedro—CIBIR, Logroño, Spain.
Instituto de Salud Carlos III. Centro Nacional de Epidemiologia. Madrid, Spain / Instituto de Salud Carlos III. CIBERESP. Madrid, Spain.
University of Basel. University Hospital Basel. Basel Institute for Clinical Epidemiology and Biostatistics, Basel, Switzerland.
University of Zurich. University Hospital Zurich. Division of Infectious Diseases and Hospital Epidemiology. Zurich, Switzerland.
Hospital Parc Tauli. Infectious Disease Department. Sabadell, Spain.
Hospital Clinic-IDIBAPS. Barcelona, Spain.
Patras University Hospital. Division of Infectious Diseases. Patras, Greece.
National and Kapodistrian University of Athens. Faculty of Medicine. Department of Hygiene, Epidemiology and Medical Statistics. Athens, Greece.
Université de Bordeaux, ISPED, Centre INSERM U1219-Epidemiologie-Biostatistique, Bordeaux, France / Université de Bordeaux. Centre INSERM U1219- Centre Inserm Epidémiologie et Biostatistique, Bordeaux, France.
Université de Bordeaux, ISPED, Centre INSERM U1219-Epidemiologie-Biostatistique, Bordeaux, France. / Université de Bordeaux. Centre INSERM U1219- Centre Inserm Epidémiologie et Biostatistique, Bordeaux, France / Bordeaux University Hospital. Department of Internal Medicine, Bordeaux, France.
Université Paris Sud, UMR 1018, le Kremlin Bicêtre, Paris, France / Inserm, UMR 1018, le Kremlin Bicêtre, Paris, France / AP-HP, Hôpital de Bicêtre, Service de Santé Publique, le Kremlin Bicêtre, Paris, France.
Inserm, UMR 1018, le Kremlin Bicêtre, Paris, France / AP-HP, Hôpital de Bicêtre, Service de Santé Publique, le Kremlin Bicêtre, Paris, France.
Southern Alberta Clinic, Calgary, AB, Canada / Department of Medicine, University of Calgary, Calgary, AB, Canada.
Southern Alberta Clinic, Calgary, AB, Canada / Department of Medicine, University of Calgary, Calgary, AB, Canada.
Instituto de Salud Carlos III. Centro Nacional de Epidemiologia. Madrid, Spain.
Instituto de Salud Carlos III. Centro Nacional de Epidemiologia. Madrid, Spain.
Fundacao Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Brasil.
Fundacao Oswaldo Cruz. Programa de Computação Científica, Rio de Janeiro, Brasil.
Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
Yale University School of Medicine. Department of Internal Medicine, New Haven.
Yale University School of Medicine. Department of Internal Medicine, New Haven / VA Connecticut Healthcare System, West Haven, CT.
Harvard T.H. Chan School of Public Health. Department of Epidemiology. Boston / Harvard T.H. Chan School of Public Health. Department of Biostatistics, Boston / Harvard-MIT Division of Health Sciences and Technology, Boston, MA.
Abstract
Clinical guidelines recommend immediate initiation of combined antiretroviral therapy for all HIV-positive individuals. However, those guidelines are based on trials of relatively young participants.
Keywords
AgingAntiretroviral treatment
CD4 Lymphocyte Count
Causal inference
Comparative Effectiveness Research
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