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EFFECT OF IMMEDIATE INITIATION OF ANTIRETROVIRAL THERAPY ON RISK OF SEVERE BACTERIAL INFECTIONS IN HIV-POSITIVE PEOPLE WITH CD4 CELL COUNTS OF MORE THAN 500 CELLS PER μL: SECONDARY OUTCOME RESULTS FROM A RANDOMISED CONTROLLED TRIAL
Terapia Antirretroviral de Alta Atividade
Infecções Bacterianas
Author
O'Connor, Jemma
Vjecha, Michael J
Phillips, Andrew N
Angus, Brian
Cooper, David
Grinsztejn, Beatriz
Lopardo, Gustavo
Das, Satyajit
Wood, Robin
Wilkin, Aimee
Klinker, Hartwig
Kantipong, Pacharee
Klingman, Karin L
Jilich, David
Herieka, Elbushra
Denning, Eileen
Abubakar, Ibrahim
Gordin, Fred
Lundgren, Jens D
Vjecha, Michael J
Phillips, Andrew N
Angus, Brian
Cooper, David
Grinsztejn, Beatriz
Lopardo, Gustavo
Das, Satyajit
Wood, Robin
Wilkin, Aimee
Klinker, Hartwig
Kantipong, Pacharee
Klingman, Karin L
Jilich, David
Herieka, Elbushra
Denning, Eileen
Abubakar, Ibrahim
Gordin, Fred
Lundgren, Jens D
Affilliation
University College London. Research Department of Infection and Population Health, London, UK.
Veterans Affairs Medical Center, Washington, DC, USA.
Research Department of Infection and Population Health, University College London, London, UK.
Oxford Centre for Clinical Tropical Medicine, Nuffield Department of Medicine, Oxford University, Oxford, UK.
The Kirby Institute, University of New South Wales, Sydney, NSW, Australia.
Instituto Nacional de Infectologia Evandro Chagas. STD and AIDS Clinical Research Laboratory, Rio de Janeiro, Brazil.
Fundación Centro de Estudios Infectológicos, Buenos Aires, Argentina.
HIV and GU Medicine, Coventry and Warwickshire Partnership Trust, University of Warwick, Coventry, UK
Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa.
Section on Infectious Diseases, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
University of Würzburg Medical Center, Department of Internal Medicine II, Würzburg, Germany
Chaingrai Prachanukroh Hospital, Chaingrai, Thailand
Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Department of Infectious and Tropical Diseases, First Faculty of Medicine, Charles University and Na Bulovce Hospital, Prague, Czech Republic
Royal Bournemouth Hospital, Bournemouth, UK.
Division of Biostatistics, University of Minnesota, Minneapolis, MN, USA.
Institute for Global Health, University College London, London, UK
Veterans Affairs Medical Center, Washington, DC, USA; The George Washington University, Washington, DC, USA.
Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Veterans Affairs Medical Center, Washington, DC, USA.
Research Department of Infection and Population Health, University College London, London, UK.
Oxford Centre for Clinical Tropical Medicine, Nuffield Department of Medicine, Oxford University, Oxford, UK.
The Kirby Institute, University of New South Wales, Sydney, NSW, Australia.
Instituto Nacional de Infectologia Evandro Chagas. STD and AIDS Clinical Research Laboratory, Rio de Janeiro, Brazil.
Fundación Centro de Estudios Infectológicos, Buenos Aires, Argentina.
HIV and GU Medicine, Coventry and Warwickshire Partnership Trust, University of Warwick, Coventry, UK
Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa.
Section on Infectious Diseases, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
University of Würzburg Medical Center, Department of Internal Medicine II, Würzburg, Germany
Chaingrai Prachanukroh Hospital, Chaingrai, Thailand
Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Department of Infectious and Tropical Diseases, First Faculty of Medicine, Charles University and Na Bulovce Hospital, Prague, Czech Republic
Royal Bournemouth Hospital, Bournemouth, UK.
Division of Biostatistics, University of Minnesota, Minneapolis, MN, USA.
Institute for Global Health, University College London, London, UK
Veterans Affairs Medical Center, Washington, DC, USA; The George Washington University, Washington, DC, USA.
Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Abstract
The effects of antiretroviral therapy on risk of severe bacterial infections in people with high CD4 cell counts have not been well described. In this study, we aimed to quantify the effects of immediate versus deferred ART on the risk of severe bacterial infection in people with high CD4 cell counts in a preplanned analysis of the START trial.
Keywords in Portuguese
Antígenos CD4Terapia Antirretroviral de Alta Atividade
Infecções Bacterianas
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