| Author | Vieira, Vinicius A | |
| Author | Avelino-Silva, Vivian I | |
| Author | Cerqueira, Natalia B | |
| Author | Costa, Dayane A | |
| Author | Costa, Priscilla R | |
| Author | Vasconcelos, Ricardo P | |
| Author | Madruga, José Valdez Ramalho | |
| Author | Moreira, Ronaldo I | |
| Author | Hoagland, Brenda Regina de Siqueira | |
| Author | Veloso,Valdiléa G. | |
| Author | Grinsztejn, Beatriz | |
| Author | Kallas, Esper Georges | |
| Access date | 2018-03-23T18:19:23Z | |
| Available date | 2018-03-23T18:19:23Z | |
| Document date | 2017 | |
| Citation | VIEIRA, Vinicius A. et al. Asymptomatic anorectal Chlamydia trachomatis and Neisseria gonorrhoeae infections are associated with systemic CD8+ T cell activation. AIDS, v. 31, n.15, p.2069-2076, set. 2017. | pt_BR |
| ISSN | 0269-9370 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/25478 | |
| Language | eng | pt_BR |
| Rights | open access | pt_BR |
| Title | Asymptomatic anorectal Chlamydia trachomatis and Neisseria gonorrhoeae infections are associated with systemic CD8+ T-cell activation | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1097/QAD.0000000000001580 | |
| Abstract | Background: Oral pre-exposure prophylaxis (PrEP) has been established as a pivotal strategy in HIV prevention. However, bacterial sexually transmitted infections (STIs), such as Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG), are also highly prevalent. Although the presence of STI-related mucosal lesions is a known risk factor for HIV acquisition, the potential increase in risk associated with asymptomatic STIs is not completely understood. Recent data demonstrated higher T cell activation is a risk factor for sexually acquired HIV-1 infection. We examined the effect of asymptomatic CT and NG anorectal infection on systemic immune activation, potentially increasing the risk of HIV acquisition. Methods: We analyzed samples from participants of PrEP Brasil, a demonstration study of daily oral emtricitabine/tenofovir disoproxil fumarate HIV PrEP among healthy men who have sex with men, for T cell activation by flow cytometry. We included 34 asymptomatic participants with anorectal swab for CT and/or NG infectiion while negative for other STIs, and 35 controls. Results: We found a higher frequency of HLA-DR+CD38+ CD8+ T cells (1.5 vs. 0.9% p<0.005) and with memory phenotype in the group with asymptomatic CT and/or NG infection. Exhaustion and senescence markers were also significant higher in this group. No difference was observed in the soluble CD14 levels. Conclusion: Our findings suggest asymptomatic anorectal CT and/or NG increase systemic immune activation, potentially increasing the risk of HIV acquisition. Regular screening and treatment of asymptomatic STIs should be explored as adjuvant tools for HIV prevention. | pt_BR |
| Affilliation | University of São Paulo School of Medicine. Division of Clinical Immunology and Allergy, São Paulo, Brazil | pt_BR |
| Affilliation | Hospital Sírio-Libanês. Instituto de Ensino e Pesquisa, São Paulo, Brazil | pt_BR |
| Affilliation | University of São Paulo School of Medicine. Division of Clinical Immunology and Allergy, São Paulo, Brazil | pt_BR |
| Affilliation | University of São Paulo School of Medicine. Division of Clinical Immunology and Allergy, São Paulo, Brazil | pt_BR |
| Affilliation | University of São Paulo School of Medicine. Department of Infectious and Parasitic Diseases, São Paulo, Brazil | pt_BR |
| Affilliation | Centro de Referência e Treinamento em DST/AIDS, São Paulo, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Rio de Janeiro, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Rio de Janeiro, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Rio de Janeiro, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Rio de Janeiro, Brazil | pt_BR |
| Affilliation | University of São Paulo School of Medicine. Division of Clinical Immunology and Allergy, São Paulo, Brazil / Hospital Sírio-Libanês. Instituto de Ensino e Pesquisa, São Paulo, Brazil | pt_BR |
| Subject | Cellular Immunity | pt_BR |
| Subject | Immune Activation | pt_BR |
| Subject | HIV | pt_BR |
| Subject | Neisseria Gonorrhoeae | pt_BR |
| Subject | Chlamydia trachomatis | pt_BR |
| Subject | PrEP | pt_BR |
| Subject | T lymphocyte | pt_BR |
| DeCS | Imunidade Celular | pt_BR |
| DeCS | HIV | pt_BR |
| DeCS | Neisseria gonorrhoeae | pt_BR |
| DeCS | Chlamydia trachomatis | pt_BR |
| Embargo date | 2018-09-30 | |
