Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/25478
Title: Asymptomatic anorectal Chlamydia trachomatis and Neisseria gonorrhoeae infections are associated with systemic CD8+ T-cell activation
Authors: Vieira, Vinicius A
Avelino-Silva, Vivian I
Cerqueira, Natalia B
Costa, Dayane A
Costa, Priscilla R
Vasconcelos, Ricardo P
Madruga, Valdez R
Moreira, Ronaldo I
Hoagland, Brenda
Veloso, Valdiléa G
Grinsztejn, Beatriz
Kallás, Esper G
Affilliation: University of São Paulo School of Medicine. Division of Clinical Immunology and Allergy, São Paulo, Brazil
Hospital Sírio-Libanês. Instituto de Ensino e Pesquisa, São Paulo, Brazil
University of São Paulo School of Medicine. Division of Clinical Immunology and Allergy, São Paulo, Brazil
University of São Paulo School of Medicine. Division of Clinical Immunology and Allergy, São Paulo, Brazil
University of São Paulo School of Medicine. Department of Infectious and Parasitic Diseases, São Paulo, Brazil
Centro de Referência e Treinamento em DST/AIDS, São Paulo, Brazil
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Rio de Janeiro, Brazil
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Rio de Janeiro, Brazil
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Rio de Janeiro, Brazil
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Rio de Janeiro, Brazil
University of São Paulo School of Medicine. Division of Clinical Immunology and Allergy, São Paulo, Brazil / Hospital Sírio-Libanês. Instituto de Ensino e Pesquisa, São Paulo, Brazil
Abstract: Background: Oral pre-exposure prophylaxis (PrEP) has been established as a pivotal strategy in HIV prevention. However, bacterial sexually transmitted infections (STIs), such as Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG), are also highly prevalent. Although the presence of STI-related mucosal lesions is a known risk factor for HIV acquisition, the potential increase in risk associated with asymptomatic STIs is not completely understood. Recent data demonstrated higher T cell activation is a risk factor for sexually acquired HIV-1 infection. We examined the effect of asymptomatic CT and NG anorectal infection on systemic immune activation, potentially increasing the risk of HIV acquisition. Methods: We analyzed samples from participants of PrEP Brasil, a demonstration study of daily oral emtricitabine/tenofovir disoproxil fumarate HIV PrEP among healthy men who have sex with men, for T cell activation by flow cytometry. We included 34 asymptomatic participants with anorectal swab for CT and/or NG infectiion while negative for other STIs, and 35 controls. Results: We found a higher frequency of HLA-DR+CD38+ CD8+ T cells (1.5 vs. 0.9% p<0.005) and with memory phenotype in the group with asymptomatic CT and/or NG infection. Exhaustion and senescence markers were also significant higher in this group. No difference was observed in the soluble CD14 levels. Conclusion: Our findings suggest asymptomatic anorectal CT and/or NG increase systemic immune activation, potentially increasing the risk of HIV acquisition. Regular screening and treatment of asymptomatic STIs should be explored as adjuvant tools for HIV prevention.
Keywords: Cellular Immunity
Immune Activation
HIV
Neisseria Gonorrhoeae
Chlamydia trachomatis
PrEP
T lymphocyte
DeCS: Imunidade Celular
HIV
Neisseria gonorrhoeae
Chlamydia trachomatis
Issue Date: 2017
Citation: VIEIRA, Vinicius A. et al. Asymptomatic anorectal Chlamydia trachomatis and Neisseria gonorrhoeae infections are associated with systemic CD8+ T cell activation. AIDS, v. 31, n.15, p.2069-2076, set. 2017.
DOI: 10.1097/QAD.0000000000001580
ISSN: 0269-9370
Copyright: restricted access
Appears in Collections:INI - Artigos de Periódicos




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