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2050-01-01
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MELATONIN EFFECT ON THE ULTRASTRUCTURE OF EHRLICH ASCITES TUMOR CELLS, LIFETIME AND HISTOPATHOLOGY IN SWISS MICE
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University Federal Rural of Pernambuco. Department of Animal Morphology and Physiology. Recife, PE, Brazil.
University Federal Rural of Pernambuco. Department of Antibiotics. Recife, PE, Brazil.
University Federal Rural of Pernambuco. Department of Animal Morphology and Physiology. Recife, PE, Brazil.
University Federal Rural of Pernambuco. Department of Histology and Embryology. Recife, PE, Brazil.
University Federal Rural of Pernambuco. Department of Animal Morphology and Physiology. Recife, PE, Brazil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunopatologia Keizo Asami (LIKA). Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunopatologia Keizo Asami (LIKA). Recife, PE, Brasil.
University Federal Rural of Pernambuco. Department of Antibiotics. Recife, PE, Brazil.
University Federal Rural of Pernambuco. Department of Animal Morphology and Physiology. Recife, PE, Brazil.
University Federal Rural of Pernambuco. Department of Histology and Embryology. Recife, PE, Brazil.
University Federal Rural of Pernambuco. Department of Animal Morphology and Physiology. Recife, PE, Brazil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunopatologia Keizo Asami (LIKA). Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunopatologia Keizo Asami (LIKA). Recife, PE, Brasil.
Abstract
One of the models used for studying cancer is the Ehrlich ascites tumor (EAT) due to its ability to grow in liquid suspension, allowing a standard number of cells to be inoculated, growth quantification and regression of tumor mass. Among the oncostatic substances, melatonin has shown effectiveness in limiting the tumor cell proliferation. However, studies have shown contradictory effects of melatonin on the EAT. This study has investigated the melatonin effect on tumor growth, time and survival percentage, ultrastructure and metastasis of EAT cells in mice submitted or not to pinealectomy.
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