Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/25577
Title: Force of infection of dengue serotypes in a population-based study in the northeast of Brazil
Authors: Castanha, P. M. S.
Cordeiro, M. T.
Martelli, C. M. T.
Souza, W. V.
Marques, E. T. A.
Braga, C.
Affilliation: Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Parasitologia. Laboratório de Doenças Transmissíveis. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil / Secretaria de Saúde de Pernambuco. Laboratório Central de Saúde Pública. Recife, PE, Brasil.
Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil / Universidade Federal de Pernambuco. Departamento de Medicina Tropical. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de saúde coletiva. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil / University of Pittsburgh. Center for Vaccine Research. Department of Infectious Diseases and Microbiology. Pittsburgh, PA, USA.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Parasitologia. Laboratório de Doenças Transmissíveis. Recife, PE, Brasil.
Abstract: This study investigated anti-dengue serotype-specific neutralizing antibodies in a random sample of dengue IgG-positive individuals identified in a survey performed in a hyperendemic setting in northeastern Brazil in 2005. Of 323 individuals, 174 (53.8%) had antibodies to dengue virus serotype 1 (DENV-1), 104 (32.2%) to DENV-2 and 301 (93.2%) to DENV-3. Monotypic infections by DENV-3 were the most frequent infection (35.6%). Of 109 individuals aged <15 years, 61.5% presented multitypic infections. The force of infection estimated by a catalytic model was 0.9%, 0.4% and 2.5% person-years for DENV-1, DENV-2 and DENV-3, respectively. By the age of 5 years, about 70%, 30% and 40% of participants were immune to DENV-3, DENV-2 and DENV-1, respectively. The data suggest that infection with DENV-1, -2 and -3 is intense at early ages, demonstrating the need for research efforts to investigate dengue infection in representative population samples of Brazilian children during early infancy.
Keywords: Dengue
Neutralizing antibody
Prevalence
keywords: Dengue
Anticorpo neutralizante
Prevalência
DeCS: Adolescente
Adulto
Anticorpos Neutralizantes / sangue
Anticorpos virais / sangue
Brasil / epidemiologia
Criança
Criança, pré-escolar
Dengue / sangue
Dengue / epidemiologia
Dengue / patologia
Dengue / virologia
Vírus da Dengue / classificação
Fêmea
Humanos
Imunoglobulina G / sangue
Masculino
Meia idade
Serotipagem
Adulto jovem
Issue Date: 2013
Citation: CASTANHA, P. M. S. et al. Force of infection of dengue serotypes in a population-based study in the northeast of Brazil. Epidemiology and Infection, v. 141, n. 5, p. 1080-1088, maio 2013.
DOI: 10.1017/S0950268812001367
ISSN: 1469-4409
Copyright: restricted access
Appears in Collections:PE - IAM - Artigos de Periódicos

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