Author | Erlandson, Kristine M | |
Author | Fiorillo, Suzanne P | |
Author | Cardoso, Sandra Wagner | |
Author | Riviere, Cynthia | |
Author | Sanchez, Jorge | |
Author | Hakim, James | |
Author | Kumarasamy, Nagalingeswaran | |
Author | Badal-Faesen, Sharlaa | |
Author | Lalloo, Umesh | |
Author | Kumwenda, Johnstone | |
Author | Campbell, Thomas B | |
Author | Brown, Todd T | |
Access date | 2018-04-03T18:34:34Z | |
Available date | 2018-04-03T18:34:34Z | |
Document date | 2017 | |
Citation | ERLANDSON, Kristine M, et al. Insulin-like Growth Factor is Associated with Changes in Body Composition with ART Initiation. AIDS Research and Human Retroviruses, v. 33, n. 9, 2017. | pt_BR |
ISSN | 0889-2229 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/25600 | |
Language | eng | pt_BR |
Rights | open access | pt_BR |
Title | Insulin-Like Growth Factor Is Associated with Changes in Body Composition with Antiretroviral Therapy Initiation | pt_BR |
Type | Article | pt_BR |
DOI | 10.1089/AID.2016.0327 | |
Abstract | Growth hormone (GH)/insulin-like growth factor (IGF)-1 axis abnormalities have been associated with body composition changes among HIV-infected persons with wasting or lipodystrophy. Little is known of GH/IGF-1 axis alterations with antiretroviral therapy (ART) initiation or differing ART therapies. The AIDS Clinical Trials Group Prospective Evaluation of Antiretrovirals in Resource-Limited Settings (PEARLS) study was a prospective, randomized clinical trial of ART initiation with emtricitabine/tenofovir + efavirenz (FTC/TDF+EFV) versus lamivudine/zidovudine + efavirenz (3TC/ZDV+EFV) in HIV-1-infected individuals from resource-diverse settings. IGF-1 was measured from baseline, week 48, and week 96 stored serum samples. Multivariate models were constructed. 415 participants were included: 170 (41%) were randomized to FTC/TDF+EFV and 245 (59%) to 3TC/ZDV+EFV. The mean age was 35 years, 60% were black, 42% women. The mean IGF-1 level did not change significantly from baseline to week 96 (-0.65 ng/ml; 95% confidence interval (CI) -5.18-3.87), p = .78 and there were no differences by treatment arm at week 96, p = .74. Lower baseline IGF-1 was associated with age, non-white race, greater waist-hip ratio (WHR), low CD4 count, and lower baseline albumin (all p < .01) but not plasma HIV-1 RNA, body mass index, or treatment arm. Greater change in IGF-1 from baseline to 96 weeks was associated with female sex, smaller WHR change, lower baseline albumin, and higher baseline HIV-1 RNA (all p < .01). ART initiation with either ZDV or TDF did not significantly impact overall IGF-1 levels. Baseline and on-treatment changes in IGF-1 with ART initiation may be related to the body composition changes that occur after ART initiation. | pt_BR |
Affilliation | University of Colorado Denver, Aurora, CO, USA | pt_BR |
Affilliation | University of Colorado Denver, Aurora, CO, USA | pt_BR |
Affilliation | Fundação Oswaldo cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Les Centres GHESKIO, Port-au-Prince, Haiti | pt_BR |
Affilliation | Asociación Civil Impacta Salud y Educación, Lima, Peru / University of Washington, Seattle, USA | pt_BR |
Affilliation | University of Zimbabwe-College of Health Sciences, Harare, Zimbabwe | pt_BR |
Affilliation | YRGCARE Medical Centre, CART CRS, Chennai, India. | pt_BR |
Affilliation | Clinical HIV Research Unit, Department of Medicine, University of Witwatersrand, Johannesburg, South Africa | pt_BR |
Affilliation | Durban International Clinical Research Site, Durban, South Africa | pt_BR |
Affilliation | College of Medicine- Johns Hopkins Project; Blantyre, Malawi | pt_BR |
Affilliation | University of Colorado Denver; Aurora, CO, USA | pt_BR |
Affilliation | Johns Hopkins University, Baltimore, MD, USA | pt_BR |
Subject | HIV | pt_BR |
Subject | Anthropomorphics | pt_BR |
Subject | Obesity | pt_BR |
Subject | Lipodystrophy | pt_BR |
Subject | Antiretroviral therapy | pt_BR |
Subject | Highly active | pt_BR |
Subject | Insulin-like growth factor-1 | pt_BR |
Embargo date | 2018-09-30 | |