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Title: Insulin-Like Growth Factor Is Associated with Changes in Body Composition with Antiretroviral Therapy Initiation
Authors: Erlandson, Kristine M
Fiorillo, Suzanne P
Cardoso, Sandra Wagner
Riviere, Cynthia
Sanchez, Jorge
Hakim, James
Kumarasamy, Nagalingeswaran
Badal-Faesen, Sharlaa
Lalloo, Umesh
Kumwenda, Johnstone
Campbell, Thomas B
Brown, Todd T
Affilliation: University of Colorado Denver, Aurora, CO, USA
University of Colorado Denver, Aurora, CO, USA
Fundação Oswaldo cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil
Les Centres GHESKIO, Port-au-Prince, Haiti
Asociación Civil Impacta Salud y Educación, Lima, Peru / University of Washington, Seattle, USA
University of Zimbabwe-College of Health Sciences, Harare, Zimbabwe
YRGCARE Medical Centre, CART CRS, Chennai, India.
Clinical HIV Research Unit, Department of Medicine, University of Witwatersrand, Johannesburg, South Africa
Durban International Clinical Research Site, Durban, South Africa
College of Medicine- Johns Hopkins Project; Blantyre, Malawi
University of Colorado Denver; Aurora, CO, USA
Johns Hopkins University, Baltimore, MD, USA
Abstract: Growth hormone (GH)/insulin-like growth factor (IGF)-1 axis abnormalities have been associated with body composition changes among HIV-infected persons with wasting or lipodystrophy. Little is known of GH/IGF-1 axis alterations with antiretroviral therapy (ART) initiation or differing ART therapies. The AIDS Clinical Trials Group Prospective Evaluation of Antiretrovirals in Resource-Limited Settings (PEARLS) study was a prospective, randomized clinical trial of ART initiation with emtricitabine/tenofovir + efavirenz (FTC/TDF+EFV) versus lamivudine/zidovudine + efavirenz (3TC/ZDV+EFV) in HIV-1-infected individuals from resource-diverse settings. IGF-1 was measured from baseline, week 48, and week 96 stored serum samples. Multivariate models were constructed. 415 participants were included: 170 (41%) were randomized to FTC/TDF+EFV and 245 (59%) to 3TC/ZDV+EFV. The mean age was 35 years, 60% were black, 42% women. The mean IGF-1 level did not change significantly from baseline to week 96 (-0.65 ng/ml; 95% confidence interval (CI) -5.18-3.87), p = .78 and there were no differences by treatment arm at week 96, p = .74. Lower baseline IGF-1 was associated with age, non-white race, greater waist-hip ratio (WHR), low CD4 count, and lower baseline albumin (all p < .01) but not plasma HIV-1 RNA, body mass index, or treatment arm. Greater change in IGF-1 from baseline to 96 weeks was associated with female sex, smaller WHR change, lower baseline albumin, and higher baseline HIV-1 RNA (all p < .01). ART initiation with either ZDV or TDF did not significantly impact overall IGF-1 levels. Baseline and on-treatment changes in IGF-1 with ART initiation may be related to the body composition changes that occur after ART initiation.
Keywords: HIV
Antiretroviral therapy
Highly active
Insulin-like growth factor-1
Issue Date: 2017
Citation: ERLANDSON, Kristine M, et al. Insulin-like Growth Factor is Associated with Changes in Body Composition with ART Initiation. AIDS Research and Human Retroviruses, v. 33, n. 9, 2017.
DOI: 10.1089/AID.2016.0327
ISSN: 0889-2229
Copyright: restricted access
Appears in Collections:INI - Artigos de Periódicos

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