Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/25608
Title: Role of TNF-Alpha, IFN-Gamma, and IL-10 in the Development of Pulmonary Tuberculosis
Authors: Cavalcanti, Yone Vila Nova
Brelaz, Maria Carolina Accioly
Neves, Juliana Kelle de Andrade Lemoine
Ferraz, José Candido
Pereira, Valéria Rêgo Alves
Affilliation: Universidade Federal Rural de Pernambuco. Departamento de Biologia. Recife, PE, Brasil / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.
Universidade Federal de Pernanbuco (UFPE). Centro Acadêmico de Vitória. Núcleo de Educação Física e Ciências do Esporte. Vitória de Santo Antão, PE, Brazil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.
Abstract: Host immune response against Mycobacterium tuberculosis is mediated by cellular immunity, in which cytokines and Th1 cells play a critical role. In the process of control of the infection by mycobacteria, TNF-alpha seems to have a primordial function. This cytokine acts in synergy with IFN-gamma, stimulating the production of reactive nitrogen intermediates (RNIs), thus mediating the tuberculostatic function of macrophages, and also stimulating the migration of immune cells to the infection site, contributing to granuloma formation, which controls the disease progression. IFN-gamma is the main cytokine involved in the immune response against mycobacteria, and its major function is the activation of macrophages, allowing them to exert its microbicidal role functions. Different from TNF-alpha and IFN-gamma, IL-10 is considered primarily an inhibitory cytokine, important to an adequate balance between inflammatory and immunopathologic responses. The increase in IL-10 levels seems to support the survival of mycobacteria in the host. Although there is not yet conclusive studies concerning a clear dichotomy between Th1 and Th2 responses, involving protective immunity and susceptibility to the disease, respectively, we can suggest that the knowledge about this responses based on the prevailing cytokine profile can help to elucidate the immune response related to the protection against M. tuberculosis.
Keywords: Pulmonary Tuberculosis
cellular immunity
immunopathology
keywords: Imunidade celular
Tuberculose pulmonar
Imunopatologia
DeCS: Tuberculose Pulmonar / patologia
Brasil / epidemiologia
Tuberculose Pulmonar / imunologia
Controle de Infecções
Estudos transversais
Issue Date: 2012
Citation: CAVALCANTI, Y. V. N. et al. Role of TNF-Alpha, IFN-Gamma, and IL-10 in the Development of Pulmonary Tuberculosis. Pulmonary Medicine, v. 2012, p. 745483, 2012.
DOI: 10.1155/2012/745483
ISSN: 2090-1844
Copyright: open access
Appears in Collections:PE - IAM - Artigos de Periódicos

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