Associations between endothelial dysfunction and clinical and laboratory parameters in children and adolescents with sickle cell anemia

Bahia Foundation for the Development of Sciences. Bahiana School of Medicine Public Health. Salvador, BA, Brazil / Federal University of Bahia. School of Medicine. Salvador, BA, Brazil
Federal University of Bahia. School of Medicine. Salvador, BA, Brazil
Bahia Foundation for the Development of Sciences. Bahiana School of Medicine Public Health. Salvador, BA, Brazil / Federal University of Bahia. School of Medicine. Salvador, BA, Brazil
Bahia Foundation for the Development of Sciences. Bahiana School of Medicine Public Health. Salvador, BA, Brazil /
Bahia Foundation for the Development of Sciences. Bahiana School of Medicine Public Health. Salvador, BA, Brazil /
University Salvador. Laureate International Universities. Salvador, BA, Brazil
Hematology and Hemotherapy Foundation of Bahia. Salvador, BA, Brazil
Bahia Foundation for the Development of Sciences. Bahiana School of Medicine Public Health. Salvador, BA, Brazil
Bahia Foundation for the Development of Sciences. Bahiana School of Medicine Public Health. Salvador, BA, Brazil / University Salvador. Laureate International Universities. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brazil / University of Salvador. Salvador, BA, Brazil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil
Bahia Foundation for the Development of Sciences. Bahiana School of Medicine Public Health. Salvador, BA, Brazil / Catholic University of Salvador. Salvador, BA, Brazil

Abstract

Hematological changes can drive damage of endothelial cells, which potentially lead to an early endothelial dysfunction in patients with sickle cell anemia (SCA). An association may exist between endothelial dysfunction and several clinical manifestations of SCA. The present study aims to evaluate the links between changes in endothelial function and clinical and laboratory parameters in children and adolescents with SCA.

Keywords in Portuguese

Anemia Falciforme
Células endoteliais
Reticulócitos
Ultrassonografia Doppler
Adolescente
Criança

Keywords

Anemia Sickle
Endothelial Cells
Reticulocytes
Ultrasonography, Doppler
Adolescent
Child

Publisher

Public Library of Science

Citation

TEIXEIRA, Rozana Santos et al. Associations between endothelial dysfunction and clinical and laboratory parameters in children and adolescents with sickle cell anemia. PLoS One, v. 12, n. 9, p. e0184076, 2017.

DOI

10.1371/journal.pone.0184076

ISSN

1932-6203

Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/25656

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Open access

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