Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/25665
Title: Adenylyl cyclase type 9 gene polymorphisms are associated with asthma and allergy in Brazilian children
Authors: Teixeira, Helena Maria Pitangueira
Neves, Neuza Maria Alcantara
Barreto, Maurício Lima
Figueiredo, Camila Alexandrina Viana de
Costa, Ryan dos Santos
Affilliation: Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
Abstract: Asthma is a chronic inflammatory disease of the respiratory tract. This heterogeneous disease is caused by the interaction of interindividual genetic variability and environmental factors. The gene adenylyl cyclase type 9 (ADCY9) encodes a protein called adenylyl cyclase (AC), responsible for producing the second messenger cyclic AMP (cAMP). cAMP is produced by T regulatory cells and is involved in the down-regulation of T effector cells. Failures in cAMP production may be related to an imbalance in the regulatory immune response, leading to immune-mediated diseases, such as allergic disorders. The aim of this study was to investigate how polymorphisms in the ADCY9 are associated with asthma and allergic markers. The study comprised 1309 subjects from the SCAALA (Social Changes Asthma and Allergy in Latin America) program. Genotyping was accomplished using the Illumina 2.5 Human Omni bead chip. Logistic regression was used to assess the association between allergy markers and ADCY9 variation in PLINK 1.07 software with adjustments for sex, age, helminth infection and ancestry markers. The ADCY9 candidate gene was associated with different phenotypes, such as asthma, specific IgE, skin prick test, and cytokine production. Among 133 markers analyzed, 29 SNPs where associated with asthma and allergic markers in silico analysis revealed the functional impact of the 6 SNPs on ADCY9 expression. It can be concluded that polymorphisms in the ADCY9 gene are significantly associated with asthma and/or allergy markers. We believe that such polymorphisms may lead to increased expression of adenylyl cyclase with a consequent increase in immunoregulatory activity. Therefore, these SNPs may offer an impact on the occurrence of these conditions in admixture population from countries such as Brazil.
Keywords: Allergy
Polymorphismc
AMP
T regulatory cells
ADCY9
Asthma
keywords: Alergia
Polimorfismo
AMP
Células reguladoras T
ADCY9
Asthma
Issue Date: 2017
Publisher: Elsevier
Citation: TEIXEIRA, H. M. P. et al. Adenylyl cyclase type 9 gene polymorphisms are associated with asthma and allergy in Brazilian children. Molecular Immunology, v. 82, p. 137–145, 2017.
Description: Barreto, Maurício Lima. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
DOI: 10.1016/j.molimm.2017.01.001
ISSN: 0161-5890
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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