| Author | Vilella, Marília | |
| Author | Costa, Gustavo Nunes de Oliveira | |
| Author | Barreto, Maurício Lima | |
| Author | Figueredo, Camila Alexandrina | |
| Author | Neves, Neuza Maria Alcantara | |
| Author | Rodrigues, Laura Cunha | |
| Author | Matos, Sheila Maria Alvim de | |
| Author | Fiaccone, Rosemeire Leovigildo | |
| Author | Oliveira, Pablo | |
| Author | Rocha, Aline | |
| Author | Silva, Rita de Cássia Ribeiro | |
| Access date | 2018-04-10T16:51:15Z | |
| Available date | 2018-04-10T16:51:15Z | |
| Document date | 2017 | |
| Citation | VILELLEA, M. et al. Effect of dietary consumption as a modifier on the association between FTO gene variants and excess body weight in children from an admixed population in Brazil: the Social Changes, Asthma and Allergy in Latin America (SCAALA) cohort study. British Journal of Nutrition, v. 117, p. 1503–1510, 2017. | pt_BR |
| ISSN | 0007-1145 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/25737 | |
| Sponsorship | Funding of Studies and Projects (FINEP, Ministry of Science and Technology, Brazil), the Brazilian National Research Council (CNPq) and The Wellcome Trust, UK, Ref 072405/Z/03/Z. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Cambridge University Press | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Ingestão dietética | pt_BR |
| Subject in Portuguese | Variantes do FTO | pt_BR |
| Subject in Portuguese | Adiposidade | pt_BR |
| Subject in Portuguese | Crianças | pt_BR |
| Title | Effect of dietary consumption as a modifier on the association between FTO gene variants and excess body weight in children from an admixed population in Brazil: the Social Changes, Asthma and Allergy in Latin America (SCAALA) cohort study | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1017/S0007114517001386 | |
| Abstract | Previous studies have shown associations of variants of the FTO gene with body weight, but none of these have involved Latin American populations with a high level of miscegenation, as is seen in the north-eastern Brazilian population. This study evaluated the association between SNP in the FTO gene and excess weight in Salvador, Bahia, Brazil. In addition, the effect of diet as a modifier on this association was also investigated. This cross-sectional study included 1191 participants aged 4-11 years, who were genotyped for 400 variants of the FTO gene. Direct anthropometric measures were made and dietary data were obtained by 24-h food recall. Multivariate logistic regression analyses were used to assess the associations of interest. Overall, 11·2 % of the individuals included in the study were overweight/obese. Interactions were identified between the percentage energy intake from proteins and obesity risk linked to the rs62048379 SNP (P interaction=0·01) and also between fat intake (PUFA:SFA ratio) and obesity risk linked to the rs62048379 SNP (P interaction=0·01). The T allele for the variant rs62048379 was positively associated with overweight/obesity in individuals whose percentage energy intake from protein was above the median (OR 2·00; 95 % CI 1·05, 3·82). The rs62048379 SNP was also associated with overweight/obesity in individuals whose PUFA:SFA ratio was below the median (OR 1·63; 95 % CI 1·05, 2·55). The association between FTO gene variants and excess body weight can be modulated by dietary characteristics, particularly by fatty acid distribution and dietary protein intake in children. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Escola de Nutrição. Departamento Ciência da Nutrição. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Ciências da Biointeração. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Matemática. Salvador, BA, Brasil | pt_BR |
| Affilliation | London School of Hygiene and Tropical Medicine. Department of Epidemiology and Population Health. London, UK | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Matemática. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Escola de Nutrição. Departamento Ciência da Nutrição. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Escola de Nutrição. Departamento Ciência da Nutrição. Salvador, BA, Brasil | pt_BR |
| Subject | Dietary intake | pt_BR |
| Subject | FTO variants | pt_BR |
| Subject | Adiposity | pt_BR |
| Subject | Children | pt_BR |
