Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/25737
Title: Effect of dietary consumption as a modifier on the association between FTO gene variants and excess body weight in children from an admixed population in Brazil: the Social Changes, Asthma and Allergy in Latin America (SCAALA) cohort study
Authors: Vilella, Marília
Costa, Gustavo Nunes de Oliveira
Barreto, Maurício Lima
Figueredo, Camila Alexandrina
Neves, Neuza Maria Alcantara
Rodrigues, Laura Cunha
Matos, Sheila Maria Alvim de
Fiaccone, Rosemeire Leovigildo
Oliveira, Pablo
Rocha, Aline
Silva, Rita de Cássia Ribeiro
Affilliation: Universidade Federal da Bahia. Escola de Nutrição. Departamento Ciência da Nutrição. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Ciências da Biointeração. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Matemática. Salvador, BA, Brasil
London School of Hygiene and Tropical Medicine. Department of Epidemiology and Population Health. London, UK
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Matemática. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
Universidade Federal da Bahia. Escola de Nutrição. Departamento Ciência da Nutrição. Salvador, BA, Brasil
Universidade Federal da Bahia. Escola de Nutrição. Departamento Ciência da Nutrição. Salvador, BA, Brasil
Abstract: Previous studies have shown associations of variants of the FTO gene with body weight, but none of these have involved Latin American populations with a high level of miscegenation, as is seen in the north-eastern Brazilian population. This study evaluated the association between SNP in the FTO gene and excess weight in Salvador, Bahia, Brazil. In addition, the effect of diet as a modifier on this association was also investigated. This cross-sectional study included 1191 participants aged 4-11 years, who were genotyped for 400 variants of the FTO gene. Direct anthropometric measures were made and dietary data were obtained by 24-h food recall. Multivariate logistic regression analyses were used to assess the associations of interest. Overall, 11·2 % of the individuals included in the study were overweight/obese. Interactions were identified between the percentage energy intake from proteins and obesity risk linked to the rs62048379 SNP (P interaction=0·01) and also between fat intake (PUFA:SFA ratio) and obesity risk linked to the rs62048379 SNP (P interaction=0·01). The T allele for the variant rs62048379 was positively associated with overweight/obesity in individuals whose percentage energy intake from protein was above the median (OR 2·00; 95 % CI 1·05, 3·82). The rs62048379 SNP was also associated with overweight/obesity in individuals whose PUFA:SFA ratio was below the median (OR 1·63; 95 % CI 1·05, 2·55). The association between FTO gene variants and excess body weight can be modulated by dietary characteristics, particularly by fatty acid distribution and dietary protein intake in children.
Keywords: Dietary intake
FTO variants
Adiposity
Children
keywords: Ingestão dietética
Variantes do FTO
Adiposidade
Crianças
Issue Date: 2017
Publisher: Cambridge University Press
Citation: VILELLEA, M. et al. Effect of dietary consumption as a modifier on the association between FTO gene variants and excess body weight in children from an admixed population in Brazil: the Social Changes, Asthma and Allergy in Latin America (SCAALA) cohort study. British Journal of Nutrition, v. 117, p. 1503–1510, 2017.
DOI: 10.1017/S0007114517001386
ISSN: 0007-1145
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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