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2030-01-01
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- IOC - Artigos de Periódicos [12776]
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CORRELATION OF HTLV-1 TAX GENETIC DIVERSITY WITH HTLV-1 ASSOCIATED MYELOPATHY/TROPICAL SPASTIC PARAPARESIS PROGRESSION AND HTLV-1A GENOTYPES IN AN HTLV-1 ENDEMIC REGION IN ARGENTINA
Genes pX
subgrupo transcontinental
Subgrupo japonês
portadores saudáveis
Argentina
healthy carriers
San Salvador de Jujuy
HAM/TSP outcome
transcontinental subgroup
Japanese subgroup
Author
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ. Brasil.
Sem afiliação
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ. Brasil.
National University of Córdoba. School of Medicine. Institute of Virology. Laboratory of Human Lymphotropic Viruses. Córdoba, Argentina.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Sistemática Bioquímica. Rio de Janeiro, RJ. Brasil.
San Roque Hospital. San Salvador de Jujuy, Argentina.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ. Brasil.
National University of Córdoba. School of Medicine. Institute of Virology. Laboratory of Human Lymphotropic Viruses. Córdoba, Argentina.
Sem afiliação
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ. Brasil.
National University of Córdoba. School of Medicine. Institute of Virology. Laboratory of Human Lymphotropic Viruses. Córdoba, Argentina.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Sistemática Bioquímica. Rio de Janeiro, RJ. Brasil.
San Roque Hospital. San Salvador de Jujuy, Argentina.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ. Brasil.
National University of Córdoba. School of Medicine. Institute of Virology. Laboratory of Human Lymphotropic Viruses. Córdoba, Argentina.
Abstract
The oncoprotein Tax was characterized genetically from a large cohort of human T-cell lymphotropic virus type 1 (HTLV-1) seropositive individuals from the most endemic region of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and HTLV-1 infection in Argentina, the province of San Salvador de Jujuy. Sixteen HAM/TSP patients and 47 HTLV-1 healthy carriers were evaluated. Six Tax genetic polymorphisms were identified and observed in 70.8% of healthy carriers and 62.5% of HAM/TSP patients. Tax genetic polymorphisms were not associated with clinical status but A8344C polymorphism statistically provide a borderline protective effect of HAM/TSP outcome. Nucleotide diversity in healthy carriers was 0.00549, whereas HAM/TSP virus population revealed a low diversity of 0.00379, suggests a positive selection for Tax protein conservation in this group. It is concluded that tax genetic polymorphisms do not increase the risk of developing HAM/TSP in this endemic region. However, in spite of the low prevalence of HTLV-1aB genotype, statistical analysis revealed an important correlation of tax genetic signatures with HTLV-1aA trans-continental subgroup.
Keywords in Portuguese
Vírus 1 Linfotrópico T HumanoGenes pX
subgrupo transcontinental
Subgrupo japonês
portadores saudáveis
Argentina
Keywords
tax genetic signatureshealthy carriers
San Salvador de Jujuy
HAM/TSP outcome
transcontinental subgroup
Japanese subgroup
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