| Author | Pérez, A. R. | |
| Author | Barbosa, S. D. Silva | |
| Author | Berbert, L. R. | |
| Author | Revelli, S. | |
| Author | Beloscar, J. | |
| Author | Savino, Wilson | |
| Author | Bottasso, O. | |
| Access date | 2018-04-12T13:12:40Z | |
| Available date | 2018-04-12T13:12:40Z | |
| Document date | 2011 | |
| Citation | PÉREZ, A. R. et al. Immunoneuroendocrine alterations in patients with progressive forms of chronic Chagas disease. Journal of Neuroimmunology, v.235, p 84–90, 2011. | pt_BR |
| ISSN | 0165-5728 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/25796 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Doença de Chagas humana | pt_BR |
| Subject in Portuguese | Citocinas | pt_BR |
| Subject in Portuguese | Doenças infecciosas | pt_BR |
| Subject in Portuguese | Hidrocortisona | pt_BR |
| Subject in Portuguese | Desidroepiandrosterona | pt_BR |
| Title | Immunoneuroendocrine alterations in patients with progressive forms of chronic Chagas disease | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.jneuroim.2011.03.010 | |
| Abstract | We studied the features of parallel immunoneuroendocrine responses in patients with different degrees of chronic Chagas myocarditis (indeterminate, mild/moderate or severe). A systemic inflammatory scenario was evident in patients with severe myocarditis compared to healthy subjects. This was paralleled by a disrupted activation of the hypothalamus-pituitary-adrenal axis, characterized by decreased concentrations of dehydroepiandrosterone-sulfate (DHEA-s) and an unbalanced cortisol/DHEA-s ratio, reinforcing the view that severe Chagas disease is devoid of an adequate anti-inflammatory milieu, likely involved in pathology. Our study constitutes the first demonstration of neuroendocrine disturbances, in parallel to a systemic inflammatory profile, during progressive human Chagas disease. | pt_BR |
| Affilliation | Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología. Rosario, Argentina. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Câncer. Departamento de Pesquisa Clínica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología. Rosario, Argentina. | pt_BR |
| Affilliation | Instituto Nacional de Câncer. Departamento de Pesquisa Clínica. Rio de Janeiro, RJ, Brasil / Universidad Nacional de Rosario. Hospital Provincial del Centenario. Cátedra y Servicio de Cardiología, Sección Chagas. Rosario, Argentina. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología. Rosario, Argentina. | pt_BR |
| Subject | Human Chagas disease | pt_BR |
| Subject | Cortisol | pt_BR |
| Subject | DHEA-s | pt_BR |
| Subject | HPA axis | pt_BR |
| Subject | cytokines | pt_BR |
| Subject | Infectious diseases | pt_BR |
| Embargo date | 2030-01-01 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
