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2030-01-01
Sustainable Development Goals
03 Saúde e Bem-Estar
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IMMUNONEUROENDOCRINE ALTERATIONS IN PATIENTS WITH PROGRESSIVE FORMS OF CHRONIC CHAGAS DISEASE
Pérez, A. R. et al. | Date Issued: 2011
Author
Pérez, A. R.
Barbosa, S. D. Silva
Berbert, L. R.
Revelli, S.
Beloscar, J.
Savino, Wilson
Bottasso, O.
Affilliation
Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología. Rosario, Argentina.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Câncer. Departamento de Pesquisa Clínica. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ. Brasil.
Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología. Rosario, Argentina.
Instituto Nacional de Câncer. Departamento de Pesquisa Clínica. Rio de Janeiro, RJ, Brasil / Universidad Nacional de Rosario. Hospital Provincial del Centenario. Cátedra y Servicio de Cardiología, Sección Chagas. Rosario, Argentina.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ. Brasil.
Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología. Rosario, Argentina.
Abstract
We studied the features of parallel immunoneuroendocrine responses in patients with different degrees of chronic Chagas myocarditis (indeterminate, mild/moderate or severe). A systemic inflammatory scenario was evident in patients with severe myocarditis compared to healthy subjects. This was paralleled by a disrupted activation of the hypothalamus-pituitary-adrenal axis, characterized by decreased concentrations of dehydroepiandrosterone-sulfate (DHEA-s) and an unbalanced cortisol/DHEA-s ratio, reinforcing the view that severe Chagas disease is devoid of an adequate anti-inflammatory milieu, likely involved in pathology. Our study constitutes the first demonstration of neuroendocrine disturbances, in parallel to a systemic inflammatory profile, during progressive human Chagas disease.
Keywords in Portuguese
Doença de Chagas humana
Citocinas
Doenças infecciosas
Hidrocortisona
Desidroepiandrosterona
 
Keywords
Human Chagas disease
Cortisol
DHEA-s
HPA axis
cytokines
Infectious diseases
 
Publisher
Elsevier
Citation
PÉREZ, A. R. et al. Immunoneuroendocrine alterations in patients with progressive forms of chronic Chagas disease. Journal of Neuroimmunology, v.235, p 84–90, 2011.
DOI
10.1016/j.jneuroim.2011.03.010
ISSN
0165-5728