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EVIDENCE THAT LIPOPOLISACCHARIDE MAY CONTRIBUTE TO THE CYTOKINE STORM AND CELLULAR ACTIVATION IN PATIENTS WITH VISCERAL LEISHMANIASIS
Oliveira, Joanna R. Santos et al. | Date Issued: 2011
Author
Oliveira, Joanna R. Santos
Regis, Eduardo G.
Leal, Cássia R. B.
Cunha, Rivaldo V.
Bozza, Patrícia T.
Cruz, Alda M. da
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil.
Universidade Federal do Mato Grosso do Sul. Departamento de Medicina Veterinária. Campo Grande, MS, Brasil.
Universidade Federal do Mato Grosso do Sul. Departamento de Clínica Médica. Campo Grande, MS, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Plataforma Luminex. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil.
Abstract
Visceral leishmaniasis (VL) is characterized by parasite-specific immunosuppression besides an intense pro-inflammatory response. Lipopolisaccharide (LPS) has been implicated in the immune activation of T-cell deficient diseases such as HIV/AIDS and idiopathic lymphocytopenia. The source of LPS is gram-negative bacteria that enter the circulation because of immunological mucosal barrier breakdown. As gut parasitization also occurs in VL, it was hypothesized that LPS may be elevated in leishmaniasis, contributing to cell activation.
Keywords in Portuguese
Leishmaniose visceral
Citocinas
Lipopolissacarídeo
Ativação celular
 
Keywords
Visceral Leishmaniasis
Lipopolisaccharide
Cytokine
Cellular Activation
 
Publisher
Public Library of Science
Citation
OLIVEIRA, Joanna R. Santos; et al. Evidence That Lipopolisaccharide May Contribute to the Cytokine Storm and Cellular Activation in Patients with Visceral Leishmaniasis. PLoS Negl Trop Dis., v.5, n.7, e1198, 10p, July 2011.
DOI
10.1371/journal.pntd.0001198
ISSN
1935-2727