Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/25800
Title: Genetic susceptibility to chronic Chagas disease: an overview of single nucleotide polymorphisms of cytokine genes
Authors: Vasconcelos, Romero H. T.
Montenegro, Silvia M. L.
Azevedo, Elisa A. N.
Gomes, Yara M.
Morais, Clarice N. L.
Affilliation: Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil / Fundação Oswaldo Cruz. Integrated Program on Chagas Disease. Rio de Janeiro, Brazil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.
Abstract: Chagas disease is a parasitic infection that is a significant public health problem in Latin America. The mechanisms responsible for susceptibility to the infection and the mechanisms involved in the development of cardiac and digestive forms of chronic Chagas disease remain poorly understood. However, there is growing evidence that differences in susceptibility in endemic areas may be attributable to host genetic factors. The aim of this overview was to analyze the genetic susceptibility to human Chagas disease, particularly that of single nucleotide polymorphisms of cytokine genes. A review of the literature was conducted on the following databases: PubMed/MEDLINE and Scopus. The search strategy included using the following terms: "Cytokines", "Single Nucleotide Polymorphisms" and "Chagas Disease". After screening 25 citations from the databases, 19 studies were selected for the overview. A critical analysis of the data presented in the articles suggests that genetic susceptibility to Chagas disease and chronic Chagas cardiomyopathy is highly influenced by the complexity of the immune response of the host. Follow-up studies based on other populations where Chagas disease is endemic (with distinct ethnic and genetic backgrounds) need to be conducted. These should use a large sample population so as to establish what cytokine genes are involved in susceptibility to and/or progression of the disease.
Keywords: Chagas disease
Cytokines
Single nucleotide polymorphisms
keywords: Doença de Chagas
Citocinas
Polimorfismos de nucleotídeo único
DeCS: Doença de Chagas / genética
Doença crônica
Citocinas / genética
Predisposição Genética para Doença
Humanos
Polimorfismo de nucleotídeo único / genética
Issue Date: 2012
Publisher: Elsevier
Citation: VASCONCELOS, R. H. T. et al. Genetic susceptibility to chronic Chagas disease: an overview of single nucleotide polymorphisms of cytokine genes. Cytokine, v. 59, n. 2, p. 203–208, ago. 2012.
DOI: 10.1016/j.cyto.2012.04.035
ISSN: 1096-0023
Copyright: restricted access
Appears in Collections:PE - IAM - Artigos de Periódicos

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