| Author | Lacerda, Leandra Linhares | |
| Author | Alves, Marcelo Ribeiro | |
| Author | Nogueira, Ana Cristina Martins de Almeida | |
| Author | Cruz, Daniella Arêas Mendes da | |
| Author | Magalhães, Danielle Aparecida | |
| Author | Dardenne, Mireille | |
| Author | Passos, Geraldo Aleixo | |
| Author | Savino, Wilson | |
| Access date | 2018-04-12T15:28:34Z | |
| Available date | 2018-04-12T15:28:34Z | |
| Document date | 2010 | |
| Citation | LACERDA, Leandra Linhares et al. RNA interference-mediated knockdown of CD49e (a5 integrin chain) in human thymic epithelial cells modulates the expression of multiple genes and decreases thymocyte adhesion. BMC Genomics, v.1, Suppl. 5, p. :S2, 13 p, 2010. | pt_BR |
| ISSN | 1471-2164 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/25815 | |
| Description | From 5th International Conference of the Brazilian Association for Bioinformatics and Computational Biology
(X-meeting 2009)
Angra Dos Reis, RJ, Brazil. 18-22 October 2009 | pt_BR |
| Language | eng | pt_BR |
| Publisher | BioMed Central | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Regulação gênica | pt_BR |
| Subject in Portuguese | adesão de células heterocelulares | pt_BR |
| Subject in Portuguese | Timócitos | pt_BR |
| Subject in Portuguese | microambiente tímico | pt_BR |
| Subject in Portuguese | células T intratímicas | pt_BR |
| Title | RNA interference-mediated knockdown of CD49e (α5 integrin chain) in human thymic epithelial cells modulates the expression of multiple genes and decreases thymocyte adhesion | pt_BR |
| Type | Article | |
| DOI | 10.1186/1471-2164-11-S5-S2 | |
| Abstract | The thymus is a central lymphoid organ, in which bone marrow-derived T cell precursors undergo a complex process of maturation. Developing thymocytes interact with thymic microenvironment in a defined spatial order. A component of thymic microenvironment, the thymic epithelial cells, is crucial for the maturation of T-lymphocytes through cell-cell contact, cell matrix interactions and secretory of cytokines/chemokines. There is evidence that extracellular matrix molecules play a fundamental role in guiding differentiating thymocytes in both cortical and medullary regions of the thymic lobules. The interaction between the integrin α5β1 (CD49e/CD29; VLA-5) and fibronectin is relevant for thymocyte adhesion and migration within the thymic tissue. Our previous results have shown that adhesion of thymocytes to cultured TEC line is enhanced in the presence of fibronectin, and can be blocked with anti-VLA-5 antibody. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Departamento de Imunologia.. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Escola de Medicina. Departamento de Genética. Grupo de Imunogenética Molecular. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Université Paris Descartes. Hôpital Necker. Centre National de la Recherche Scientifique. Paris, France. | pt_BR |
| Affilliation | Universidade de São Paulo. Escola de Medicina. Departamento de Genética. Grupo de Imunogenética Molecular. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | gene regulation | pt_BR |
| Subject | heterocellular cell adhesion | pt_BR |
| Subject | gene regulation | pt_BR |
| Subject | thymocytes | pt_BR |
| Subject | thymic microenvironment | pt_BR |
| Subject | cd49E | pt_BR |
